Synonyms: Gerontine; Musculamine; N,N′-Bis(3-aminopropyl)-1,4-diaminobutane; Neuridine
Formula: NH2(CH2)3NH(CH2)4NH(CH2)3NH2 · 2H2O
Formula Weight: 238.37
CAS No.: 403982-64-9
Purity: ≥99.5% (GC)
Storage Temperature: 2-8°C
Biochem/physiol Actions: Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Other Notes: Polyamines: Review1; Inhibitor of ATPase2,3; DNA polymerase4; ribonuclease5
λ: 1 M in H2O
Anion Traces: sulfate (SO42-): ≤50 mg/kg
Assay: ≥99.5% (GC)
Cation Traces: Mg: ≤5 mg/kg
Gene Information: human ... GRIN2B
rat ... Grin2
Impurities: insoluble matter, passes filter test
MP: 63-64°C
pH: 12.0-13.5 (25°C, 1 M in H2O)
Product Line: BioUltra
Solubility: H2O: soluble1 M at 20°C, clear, colorless
Storage Temp.: 2-8°C
UV Absorption: λ: 260 nm Amax: 0.20