Synonyms: alpha-Toluenesulfonyl fluoride; Benzylsulfonyl fluoride; PMSF; Phenylmethylsulfonyl fluoride
CAS Number: 329-98-6
Formula: C7H7FO2S
Formula Weight: 174.19
Linear Formula: C7H7FO2S
MDL No.: MFCD00007424
Purity: >=98.5% (GC)
Beilstein Registry Number: 2088311
EC Number: 206-350-2
UNSPSC Code: 12352202
Application: Inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase. Not as effective or as toxic as DFP. Effective concentration 0.1-1 mM. Half-life = 1 hr. at pH 7.5.
Application: Phenylmethanesulfonyl fluoride has been used in following applications:. cell fractionation.. used as a supplement in nuclear protein extraction.. inhibitor of cholesterol esterase (CE) and pseudocholinesterase (PCE).. used for the collection of blood prior to centrifugation to quantify plasma ANP levels.
Biochem/physiol Actions: Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.
RTECS: XT8040000
RIDADR: UN 2928 8(6.1) / PGII
WGK Germany: 3
R Codes: 25-34
S Codes: 26-36/37/39-45
IOD Codes: T
Symbol: GHS05, GHS06
Signal Word: Danger
Hazard Statements: H301-H314
Precautionary statements: P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338