3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester =95%, powder

Synonym: N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP

CAS Number: 68181-17-9

Empirical Formula (Hill Notation): C₁₂H₁₂N₂O₄S₂

Molecular Weight: 312.36

Beilstein Registry Number: 1548137

EC Number: 269-034-3

MDL Number: MFCD00009636

PubChem Substance ID:24898409

Application
A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Incorporates 4 atom linker.

Packaging
25, 100 mg in poly bottle; 5 mg in glass bottle