Synonyms: Monoclonal Anti-Cytokeratin, pan (mixture); Panck Antibody; Panck Antibody - Monoclonal Anti-Cytokeratin, pan (Mixture) antibody produced in mouse
MDL No.: MFCD00164710
Storage: -20C
UNSPSC Code: 12352203
Application: Monoclonal Anti-Cytokeratin, pan (Mixture) antibody produced in mouse is suitable for the following applications:. Immunohistochemistry (formalin-fixed, paraffin-embedded sections) using protease-digested sections of human or animal tissues.. Immunohistochemistry (frozen sections).. Indirect immunofluorescence (at a working dilution of 1:100 using protease-digested, formalin-fixed, paraffin-embedded sections of human or animal tissues).. Immunocytochemical labeling (immunofluorescence ) of cells.. Western blotting.
Biochem/physiol Actions: Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in the epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.
Immunogen: mixture of several monoclonal cytokeratin clones.
Specificity: This is a mixture of monoclonal anti-cytokeratin antibodies. It recognizes human cytokeratins 1,4,5,6,8,10,13,18, and 19. It is a broad spectrum reagent, which reacts specifically with a wide variety of normal, reactive, and neoplastic epithelial tissues. The antibody mixture reacts with simple, cornifying and non-cornifying squamous epithelia and pseudostratified epithelia. It does not react with non-epithelial normal human tissues. Increased staining intensity is seen following proteolytic treatment (protease unmasking).
RIDADR: NONH for all modes of transport
WGK Germany: 3
R Codes: 22
IOD Codes: Xn