JSH-23, >=98% (HPLC), solid

Synonyms: 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

CAS Number: 749886-87-1

Formula: C16H20N2

Formula Weight: 240.34

Linear Formula: C16H20N2

Purity: >=98% (HPLC)

Storage: -20C

UNSPSC Code: 12352200

Application: JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Biochem/physiol Actions: JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Other Notes: Light and air sensitive.