Synonyms: 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
CAS Number: 749886-87-1
Formula: C16H20N2
Formula Weight: 240.34
Linear Formula: C16H20N2
Purity: >=98% (HPLC)
Storage: -20C
UNSPSC Code: 12352200
Application: JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
Biochem/physiol Actions: JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.
Other Notes: Light and air sensitive.
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
R Codes: 22-41-50/53
S Codes: 26-39-60-61
IOD Codes: Xn,N
Symbol: GHS05, GHS07, GHS09
Signal Word: Danger
Hazard Statements: H302-H318-H400
Precautionary statements: P273-P280-P305 + P351 + P338