Synonyms: Everolimus; 40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxyethyl)-rapamycin; RAD 001; RAD001; SDZ-RAD; 42-O-(2-Hydroxyethyl)rapamycin
Molecular Formula: C53H83NO14
Molecular Weight: 958.22
Linear Structural Formula: C53H83NO14
MDL Number: MFCD00929329
Purity: >=95% (HPLC)
Application: Everolimus has been used as an mechanistic target of rapamycin complex 1 (mTORC1) inhibitor to study its effect on MCF7 and MDA-MB-231 cell lines.
Biochem Physiol Actions: Everolimus, the 40-O-(2-hydroxyethyl) derivative of rapamycin (sirolimus), is a potent and selective inhibitor of mechanistic target of rapamycin (mTOR). Everolimus is selective for the mTORC1 protein complex. Everolimus exhibit potent immunosuppressive and anticancer activities.