Synonyms: Trimethoprim-Sulfamethoxazole; TMP-SMX
CAS Number: 8064-90-2
Formula: C14H18N4O3 · 5 C10H11N3O3S
Formula Weight: 1556.71
Linear Formula: C14H18N4O3 · 5 C10H11N3O3S
Storage: -20C
UNSPSC Code: 51101500
Application: Cotrimoxazole has been used as an antimicrobial agent.
Biochem/physiol Actions: Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.
Preparation Note: prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
RTECS: UV8240000
RIDADR: NONH for all modes of transport
WGK Germany: 3
R Codes: 36/37/38-43
S Codes: 26-36/37
IOD Codes: Xi
Symbol: GHS07
Signal Word: Warning
Hazard Statements: H315-H317-H319-H335
Precautionary statements: P261-P280-P305 + P351 + P338