Synonyms: 1,3,7-Trimethylxanthine
Formula: C8H10N4O2
Formula Weight: 194.19
CAS No.: 58-08-2
Biochem/physiol Actions: A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.
Other Notes: Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1778.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Packaging: Supplied in amber screw-cap vials
Gene Information: human ... ADORA1, ADORA2B
Grade: Sigma Reference Standard
MP: 234-236.5°C(lit.)
Packaging: vial of 250 mg