BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C-N, C-O, C-F, C-CF3, and C-S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to -40 C, and can be used in a variety of cross-coupling protocols.
Synonyms: (BrettPhos) palladium(II) phenethylamine chloride; BrettPhos Palladacycle; BrettPhos precatalyst; Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4', 6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
Molecular Formula: C43H63ClNO2PPd
Molecular Weight: 798.81
Linear Structural Formula: C43H63ClNO2PPd
Purity: 97%
Melting Point: 198-204 C
Application: Application Guide for Palladium Catalyzed Cross-Coupling ReactionsCatalyst for:
•C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
•Amination reaction
•N-arylation of aminophenols