Synonyms: Blasticidin S
CAS Number: 589205
Formula: C17H26N8O5 · HCl
Formula Weight: 458.9
Linear Formula: C17H26N8O5 · HCl
MDL No.: MFCD02091640
Storage: -20C
UNSPSC Code: 51101500
General description: Blasticidin S belongs to the aminoacylnucleoside class of antibiotics. It inhibits protein synthesis in bacteria and eukaryotes. It also has fungicidal properties and prevents rice blast disease.
General description: Chemical structure: nucleoside
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Application: Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells . It is also used to study protein synthesis at the level of peptide bond formation.
Biochem/physiol Actions: Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
RIDADR: UN 2811 6.1 / PGII
WGK Germany: 2
R Codes: 28
S Codes: 28-36/37-45
IOD Codes: T+
Symbol: GHS06
Signal Word: Danger
Hazard Statements: H300
Precautionary statements: P264-P301 + P310