Synonyms: Anti-BL2; Anti-CADM1 Isoform 1 of Cell adhesion molecule 1 precursor; Anti-IGSF4; Anti-IGSF4A; Anti-NECL2; Anti-RA175; Anti-ST17; Anti-SYNCAM; Anti-TSLC1; Anti-sTSLC-1; Anti-sgIGSF; Anti-synCAM1
MDL No.: MFCD07370522
UNSPSC Code: 12352203
General description: Cell adhesion molecule 1 (CADM1) is a protein encoded by the CADM1 gene in humans. It is a lung epithelial cell adhesion molecule that belongs to immunoglobulin superfamily and is expressed as several isoforms (SP4, SP1, SP6) in human lung mast cells (HLMCs) with SP4 dominant.
Application: Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CADM1 (178-190) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2,000.
Biochem/physiol Actions: Cell adhesion molecule 1 (CADM1) acts as a major receptor for the adhesion of mast cells (MCs) to fibroblasts, human airway smooth muscle cells (HASMCs) and neurons. It regulates E-cadherin and Î±6Î²4 integrin in different cell types. It generates two membrane associated C-terminal fragments (CTFs), Î±CTF and Î²CTF through protease mediated ectodomain shedding. CADM1 ectodomain shedding causes alveolar cell apoptosis in emphysematous lungs by producing Î±CTF.
Immunogen: synthetic peptide corresponding to amino acids 178-190 of human CADM1
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
RIDADR: NONH for all modes of transport
WGK Germany: 2