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MilliporeSigma

Anti-CADM1 (178-190) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

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Synonyms: Anti-BL2; Anti-CADM1 Isoform 1 of Cell adhesion molecule 1 precursor; Anti-IGSF4; Anti-IGSF4A; Anti-NECL2; Anti-RA175; Anti-ST17; Anti-SYNCAM; Anti-TSLC1; Anti-sTSLC-1; Anti-sgIGSF; Anti-synCAM1

MDL No.: MFCD07370522

Storage: -20C

UNSPSC Code: 12352203

General description: Cell adhesion molecule 1 (CADM1) is a protein encoded by the CADM1 gene in humans. It is a lung epithelial cell adhesion molecule that belongs to immunoglobulin superfamily and is expressed as several isoforms (SP4, SP1, SP6) in human lung mast cells (HLMCs) with SP4 dominant.

Application: Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CADM1 (178-190) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2,000.

Biochem/physiol Actions: Cell adhesion molecule 1 (CADM1) acts as a major receptor for the adhesion of mast cells (MCs) to fibroblasts, human airway smooth muscle cells (HASMCs) and neurons. It regulates E-cadherin and α6β4 integrin in different cell types. It generates two membrane associated C-terminal fragments (CTFs), αCTF and βCTF through protease mediated ectodomain shedding. CADM1 ectodomain shedding causes alveolar cell apoptosis in emphysematous lungs by producing αCTF.

Immunogen: synthetic peptide corresponding to amino acids 178-190 of human CADM1

Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

RIDADR: NONH for all modes of transport

WGK Germany: 2

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Product Detail
Thomas No.
C962Q17
Mfr. No.
C2121-200UL
Description
Anti-CADM1 (178-190) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution, 200 uL

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