Amyloid beta Protein Fragment 1-40, >=90% (HPLC), powder

Synonyms: Abeta40

CAS Number: 131438-79-4

Formula: C194H295N53O58S

Formula Weight: 4329.8

Linear Formula: C194H295N53O58S

MDL No.: MFCD00130509

Purity: >=90% (HPLC)

Storage: -20C

UNSPSC Code: 12352202

Amino Acid Sequence: Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Biochem/physiol Actions: Amyloid beta-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. beta-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer's disease.

Reconstitution: For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 C for 4 days.

Other Notes: Lyophilized from 0.1% TFA in H2O