MDL No.: MFCD02097177
Storage: -20C
UNSPSC Code: 12352203
General description: Tyk2 is a member of the Jak family of protein tyrosine kinases. It associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and IFN-a and beta. Following ligand binding, Tyk2 is activated by phosphorylation of Tyr1054 and/or Tyr1055. Tyk2 is required for the tyrosine phosphoryla-tion of Stat3 in the IFN-beta signaling cascade.
Immunogen: synthetic phospho-Tyr1054/1055 peptide corresponding to residues around Tyr1054/1055 of human Tyk2.
Physical form: Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 mug/ml bovine serum albumin and 50% glycerol
Specificity: Detects human Tyk2 only when phosphorylated at Tyr1054/1055.
RIDADR: NONH for all modes of transport
WGK Germany: 1