The melanocyte-specific protein PMEL (also known as Pmel17, gp100, melanocyte protein, premelanosome protein or silver locus protein homolog (SILV)) is a type I transmembrane glycoprotein that is expressed primarily in pigment cells of the skin and eye. In melanosomes, the protein forms a fibrillar matrix on which the UV-shielding pigment melanin is deposited.1-2
Synonyms: ME20-M (ME20M) Melanoma-associated ME20 antigen; Melanocyte protein; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma gp100; P1; P100; Premelanosome protein; Silver locus protein homolog
Storage: -20C
Application: The antibody may be used in various immunochemical techniques including Immunoblotting (~100 kDa), Immunohistochemistry and Immunofluorescence.Detection of the PMEL band by Immunoblotting is specifically inhibited by the immunogen.
Biochem Physiol Actions: PMEL fibrils are a major functional component of the melanosomal compartment as they optimize melanin polymerization, condensation and storage.1,3PMEL fibrils have an amyloidogenic nature and share features with pathological amyloids.4 Mutations in PMEL are associated with pigmentation disorders and/or impairments in eye development in various species.1,5,6 PMEL is suggested an excellent model system to study mechanisms of intracellular amyloid formation.1