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MilliporeSigma

Anti-NCOA6 antibody produced in rabbit Prestige Antibodies(R) Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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NCOA6 (Nuclear receptor coactivator 6) encodes a novel human nuclear receptor coactivator protein. Its modular structure is composed of a large intrinsic glutamine-rich activation domain and a single functional LXXLL motif. LXXLL motif helps to associate with the members of the steroid hormone and thyroid hormone/retinoid receptor subfamilies. In humans, it consists of a potent N-terminal activation domain (AD1) and a second activation domain (AD2). It is copiously expressed in several reproductive organs such as testis, prostate, ovary and also in brain.

Synonyms: Anti-ASC-2 antibody produced in rabbit; Anti-Activating signal cointegrator 2 antibody produced in rabbit; Anti-Amplified in breast cancer protein 3 antibody produced in rabbit; Anti-Cancer-amplified transcriptional coactivator ASC-2 antibody produced in rabbit; Anti-Nuclear receptor coactivator 6 antibody produced in rabbit; Anti-Peroxisome proliferator-activated receptor-interacting protein antibody produced in rabbit

Storage: -20C

Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Biochem Physiol Actions: NCOA6 (Nuclear receptor coactivator 6) interacts with nuclear receptors in ligand-dependent or ligand-enhanced dependent manner to regulate nuclear receptor mediated mammalian gene expression. The activation domain helps to increase the transcriptional activity of several nuclear receptors. It forms dimer by binding to the liganded receptors which leads to a structural change in NRC activation. It has also been reported that NCOA6 highly influences the binding of CREB-binding protein (CBP) during transcriptional activity of nuclear hormone receptors.

Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

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Product Detail
Thomas No.
CHM03C658
Mfr. No.
HPA004198-25UL
Description
HPA004198-25UL, Anti-NCOA6 antibody produced in rabbit Prestige Antibodies(R) Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

list price/quantitytotal
$0.00
Thomas No.
CHM03C659
Mfr. No.
HPA004198-100UL
Description
HPA004198-100UL, Anti-NCOA6 antibody produced in rabbit Prestige Antibodies(R) Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

list price/quantitytotal
$0.00
$0.00 (0 Items)
Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

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