Methylcrotonoyl-CoA carboxylase 1a (MCCC1) is localized in the mitochondrion. The gene encoding the protein is present on chromosome 3q26-q28 and it consists of 19 exons.
Synonyms: Anti-3-methylcrotonyl-CoA carboxylase 1; Anti-3-methylcrotonyl-CoA carboxylase biotin-containing subunit; Anti-3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; Anti-MCCase subunit alpha; Anti-Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: As part of the 3-methylcrotonoyl-CoA carboxylase protein complex, methylcrotonoyl-CoA carboxylase 1a (MCCC1) catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, utilizing ATP and bicarbonate.
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