Diacylglycerol kinase ? (DGKH) is encoded by the gene mapped to human chromosome 13q14. The encoded protein belongs to the type II diacylglycerol kinase (DGK) enzyme family. DGKH has two alternatively spliced transcript variants encoding different isoforms namely, ?1 and ?2. Both the isoforms contain catalytic a and b subdomains and N-terminal pleckstrin homology domain (PH) in common. DGKH ?2 isoform has sterile a-motif domain at its C terminal end, whereas it is absent in ?1 isoform.
Synonyms: Anti-Dgketa; Anti-Diacylglycerol kinase, eta
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Diacylglycerol kinase ? (DGKH) is a vital constituent of lithium-sensitive phosphatidyl inositol pathway. The encoded protein plays an essential role in the regulation of intracellular concentrations of two bioactive lipids, including diacylglycerol and phosphatidic acid. DGKH functions as a potential cellular sensor for phosphatidylinositol (PI) 4,5-bisphosphate (PI(4,5)P2). Mutations in the gene are associated with bipolar disorder (BPD), adult attention-deficit/hyperactivity disorder (aADHD) and unipolar depression (UPD). In addition, variations in the gene expression also increase the risk of susceptibility to calcium oxalate stone and hypercalciuria.
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