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MilliporeSigma

Anti-CD22 Antibody, clone CY34 clone CY34, from mouse

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B-cell receptor CD22 (UniProt P20273; also known as B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14) is encoded by the Cd22 (also known as A530093D23, Lyb-8, Lyb-8a, Lyb8, Siglec2) gene (Gene ID 12483) in murine species. Murine CD22 (mCD22) is a B cell-associated adhesion protein with seven extracellular Ig-like domains that has 62% amino acid homology to its human orthologue. CD22 is expressed at multiple stages during B cell ontogeny. Cytoplasmic hCD22 can be detected at the pro-B and pre-B, whereas expression of surface hCD22 tightly correlates with that of surface immunoglobulins (sIg), especially that of sIgD. Expression of hCD22 ceases upon B cell activation and terminal differentiation into plasma cells. Only the CD22+ subpopulation among sIgM+ tonsillar B cells can be stimulated by sIg cross-linking to induce intracellular calcium, which can be further enhanced by anti-CD22 treatment prior to sIg cross-linking. Crosstalk between CD22 and sIgM is also supported by the finding that CD22 can associate with sIgM and cross-linking of sIg can stimulate rapid tyrosine phosphorylation of CD22.

Synonyms: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22

Application: This Anti-CD22 Antibody, clone CY34 is validated for use in Flow Cytometry and Immunoprecipitation for the detection of CD22.

Other Notes: Concentration: Please refer to lot specific datasheet.

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Product Detail
Thomas No.
CHM03G877
Mfr. No.
MABF980
Description
MABF980, Anti-CD22 Antibody, clone CY34 clone CY34, from mouse

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