The gene BICC1 (BicC family RNA binding protein 1) is mapped to human chromosome 10q21.1. The gene encodes an RNA binding protein. In brain, BICC1 exists in many isoforms. The protein has three RNA-binding K-homology (KH) domains and a sterile a motif (SAM).
Synonyms: Anti-Bicaudal C Homolog 1 (Drosophila)
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: BICC1 (BicC family RNA binding protein 1) is involved in cytoskeletal organization and cell-to-cell communication. The protein has a sterile a motif (SAM) domain which can stop Wnt signaling, thereby influencing the pathophysiology of depression. The BICC1 gene is upregulated in the post-mortem brains of people with major depressive disorder. In rat models, BICC1 is associated with chronic stress and use of antidepressants reduces its expression. BICC1 also controls PKD2 (polycystin 2, transient receptor potential cation channel) mRNA levels and thereby works as a genetic factor for osteoblastogenesis and bone marrow density. Mutations in this gene, which result in Wnt hyperactivity, are associated with cystic renal dysplasia.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC