2-(Pyridin-2-yl)isopropyl amine (PIP-amine) is a tertiary amine. A bidentate directing group, useful for the functionalization of C-H bond, has been developed from PIP-amine.
Synonyms: PIP; PIP Directing Group; Shi Auxilliary
Molecular Formula: C8H12N2
Molecular Weight: 136.19
Linear Structural Formula: C8H12N2
MDL Number: MFCD08729302
Purity: 95% (GC)
Density: 0.9800 g/mL at 25 C
Refractive Index: n/D 1.516
Application: The Shi Auxiliary is a powerful directing group for the hydroxylation of arenes through copper-mediated C-H activation. This useful auxiliary can be removed through acid-mediated hydrolysis and has shown to be done on gram-scale.
Other Notes: Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary