Deoxyribonucleic Acid is a polynucleotide . It is an essential component of chromosomes in cell nuclei. It is the carrier of genetic material. It contains information in chemical code to direct the development of the cell according to its inheritance. The purine and pyrimidine bases of the nucleosides are primarily adenine, guanine, cytosine and thymine. The sugar is D-2-deoxyribose. The nucleosides are linked together by phosphates in diester linkage from the 3'-hydroxyl of one sugar to the 5'-hydroxyl of the next. The repeating sugar-phosphate linkage forms the backbone of the single polynucleotide strand which is the primary structure of DNA. Chemical analysis of DNA from different species show that the purine content is equal to the pyrimidine content; adenine content equal to thymine; guanine equal to cytosine. DNA also acts as a template in the formation of ribonucleic acids, which play a fundamental role in the synthesis of proteins in the cell.
Deoxyribonucleic acid sodium salt has been used in a study to evaluate the cytotoxicity of enzyme inhibitors and absorption enhancers in Caco-2 cells for oral delivery of salmon calcitonin. Deoxyribonucleic acid sodium salt has also been used in a study to develop a simple method for extracting DNA from Cryptosporidium oocysts.
Key Applications: Substrate for development of DNA detection assays
Application Areas: Molecular Biology
Product Type: Biochemicals
Biochemical Category: Nucleotides & Nucleic Acids
Chemical Class: Nucleotides & Nucleic Acids
Presentation: Cream Colored Powder
Format: Powder
Loss on Drying: ≤15%
NOTES: Not Highly Polymerized (DNA which may have gone through some denaturization after isolation)
Solubility: Most DNA is soluble in water or aqueous buffers. Slight heating may help. The addition of SDS or similar detergent may help solubilize DNA; however, detergents tend to denature the DNA into shorter strands.
Storage & Handling: Store at +4°C. Store dessicated.