SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells.
SARS-CoV-2 Neutralizing Antibody (R323IgM), Human Chimeric is produced from cell culture in vitro under conditions free from animal-derived components.
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA detection: 0.05-1 µg/ml
Synonyms 2019-nCoV Neutralizing IgM Antibody,SARS-CoV-2 S1 RBD IgM antibody.
Description SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. SARS-CoV-2 Neutralizing Antibody (R323IgM), Human Chimeric is produced from cell culture in vitro under conditions free from animal-derived components.
Conjugation Unconjugated
Purification Affinity chromatography Clone R323IgM (monoclonal antibody) Properties Subclass Recombinant human IgM
Concentration 1 mg/ml, supplied in 0.2 μm filtered PBS, pH 7.2. Specificity The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.
Storage Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed. Avoid repeated freezing and thawing cycles. Note GenScript can customize this product per customer's request including product size, buffer components, etc.
Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA detection: 0.05-1 µg/ml
Other applications: user-optimized