Streptomycin Sulfate is an aminoglucoside antibiotic in which streptidine is linked glycosidically to the disaccharide streptobiosamine.
- Inhibit bacterial protein synthesis
- Gram positive bacteria
- Gram negative bacteria
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Specific Activity: ≥650 u/mg
Key Applications: Antibiotic
Application Areas: Antibiotic
Product Type: Biochemicals
Biochemical Category: Antibiotics
Chemical Class: Antibiotics
Optical Rotation: -77 to -79° (c=1% in H2O, 25°C) (lit.)
Presentation: White Powder
Half life: half-life in plasma is about 2-4 hours
Detection Method: FTIR
Loss on Drying: ≤7.0%
Solubility: Soluble in 4% aq soln-Clear, Colorless Solution.
Storage & Handling: +4°C