Gentamicin Sulfate is a bactericidal antibiotic of the aminoglycoside group produced by fermentation of Micromonospora purpurea or M. echinospora. It is a mixture of 3 major components designated as C1, C1a, and C2. Gentamicin is used as the sulfate salt. Each component consists of five basic nitrogens and requires five equivalents of sulfuric acid per mole of gentamicin base.
Gentamicin sulfate is a broad spectrum antibiotic. It inhibits the growth of a wide variety of Gram-positive and Gram-negative microorganisms, including strains resistant to tetracycline, chloramphenicol, kanamycin, and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus, and Streptococcus. Gentamicin sulfate inhibits bacterial protein biosynthesis by binding to the 30S subunit of the ribosome. It is used as a selection agent (gentamicin-resistance gene) in molecular biology applications.
Mode of Action: Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.
Potency: ≥590 µg/mg (dry basis), ≥483.8 µg/mg (as is)
Suitability: Suitable for cell culture
Key Applications: Selection Agent
Application Areas: Cell Biology & Analysis
Product Type: Biochemicals
Biochemical Category: Antibiotics
Chemical Class: Antibiotics
Presentation: Clear, Colorless to Pale Yellow Liquid
pH: 4.0 - 6.0
Storage & Handling: +4°C
Certifications: USP Quality