Chlorhexidine digluconate, a bis(biguanide) family cationic broad spectrum antibiotic is an antiseptic and disinfectant agent. It is effective against a wide range of bacteria, some fungi and some viruses, and an agent for the prevention of gingivitis. Chlorhexidine digluconate solution inhibits oxygen utilization which leads to a reduction in bacterial ATP. Commercial ophthalmic products have used this agent to replace thimerosal as a preservative; however, it can cause skin irritation.
Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. It has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation studies. Chronic rinsing with chlorhexidine has been shown to decrease the saltiness of NaCl and the bitterness of quinine. Used in conjuction with cetyltrimethylammonium bromide (CTAB) can increase its effectiveness.
Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
Concentration: 20% Aqueous Solution
Key Applications: Antiseptic, Disinfectant
Application Areas: Antiseptic and disinfectant agent
Product Type: Biochemicals
Density: 1.06 g/mL at 25°C(lit.)
Format: Aqueous solution
pH: 4.8 - 7.0
Sterilization of Solutions: Dilute solutions of chlorhexidine (<1.0% w/v) may be sterilized by autoclaving at 115°C for 30 minutes or at 121-123°C for 15 minutes.
Storage & Handling: Store at +4°C, Protect from light