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Ampicillin is a semi-synthetic derivative of penicillin, active as a broad-spectrum antibiotic. It is inactivated by beta-lactamases and for this reason a beta-lactamase inhibitor should be considered when using ampicillin. Against gram-positive bacteria, ampicillin has a similar mode of action as benzylpenicillin; against gram-negative bacteria, it has a similar mode of action as chloramphenicol and tetracyclines. In E. coli it inhibits cell wall synthesis.

Ampicillin is used to select bacteria cells with specific resistance during general microbiology studies. It is used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.

Ampicillin is a β-lactam antibiotic with an amino group attached to the penicillin structure. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli. Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Grade: Anhydrous

Key Applications: Antibacterial, Antibiotics

Product Type: Biochemicals

Biochemical Category: Antibiotics

Melting Point: 208°C decomposes

Presentation: White Powder

Format: White Powder

pH: 4.51 (Lit.)

pKa: pKa = 2.5 (-COOH) pKa = 7.3 (-NH2) at 25°C

Water Content: <1%

Solubility: Soluble in 1 M Ammonium Hydroxide (50 mg/mL), dilute acids or bases; slightly soluble in water; practically insoluble in alcohol, chloroform, ether and fixed oils.

Storage & Handling: Store at +4°C.

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Product Detail
Thomas No.
C825K64
Mfr. No.
219014605
Pkg. Size
5g
CAS #
69-53-4
Description
Ampicillin, 5g

Grade
Anhydrous
Pkg. Type
Amber Glass Bottle
list price/quantitytotal
$0.00
Thomas No.
C825K65
Mfr. No.
0219014625
Pkg. Size
25g
CAS #
69-53-4
Description
Ampicillin, 25g

Grade
Anhydrous
Pkg. Type
Amber Glass Bottle
list price/quantitytotal
$0.00
Thomas No.
C825K66
Mfr. No.
0219014680
Pkg. Size
100g
CAS #
69-53-4
Description
Ampicillin, 100g

Grade
Anhydrous
Pkg. Type
Amber Glass Bottle
list price/quantitytotal
$0.00
$0.00 (0 Items)
Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

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