Glycine is a non-chiral amino acid that can be synthesized in the body from the amino acid serine by Serine Hydroxymethyltransferase.
- Acts as an inhibitory neurotransmitter
- Shown to block NMDA-stimulated dopamine release in fetal mesencephalic cell cultures
- Increase NMDA-receptor mediated synaptic potential in cortical neurons
Glycine does not have a chiral center, so it is the only amino acid with no asymmetric carbon. Therefore, it does not have a D- or L- isomer designation. This material is synthetic.It is the smallest of the 20 natural amino acids. Glycine is commonly used as a component in Tris-glycine and Tris-glycine-SDS running buffers for polyacrylamide gel electrophoresis, a component of Towbin's transfer buffer for Western blots, a buffer substance in cryoenzymology, in osmotic pressure maintenance in isoelectric focusing of erythrocytes, salting-in effect in protein chemistry, and as a buffer component in the coupled phosphatase-kinase reaction for end labelling of restriction fragments. The growth requirements of various microorganisms is reported in the Handbook of Microbiology.
Key Applications: Inhibitory neurotransmitter, Buffer, Cryoenzymology, Growth supplement
Application Areas: Cell biology & Analysis, Molecular biology
Product Type: Biochemicals
Biochemical Category: Amino Acids & Peptides
Chemical Class: Amino Acids & Peptides
Density: 1.16 g/mL
Melting Point: start to decompose at 233°C, completely sintered at 290°C
Isoelectric point (pI): 6.06 pKa: for the α carboxyl group: 2.35; and for the α amino group: 9.78 at 25 °C
Loss on Drying: ≤0.5%
Solubility: Soluble in water (250 mg/mL at 25°C; 672 mg/mL at 100°C); slightly soluble in alcohol and ethanol(95%); almost insoluble in ether.
Storage & Handling: Store at Room Temperature (15-30°C).