Formic Acid is the smallest of the carboxylic acids. It is originally obtained from the distillation of ants and is a strong reducing agent.
Formic acid is a reagent used for formylation, hydrolysis, and cyclocondensations. It has also been used in the dyeing of natural and synthetic fibers, feed and fodder preservation, leather tanning, the production of commercial cleaning products and in rubber coagulation. In organic synthesis, it has been used in the synthesis of such classes of compounds as coumarins, optically active styrene oxides, and polyamide oligomers based on 14-amino - 3,6,9,12 - tetraoxatetradecanoic acid. It can be used in the mobile phase for various LC-MS analytical methods, such as an LC-MS study of spiroketal stereoisomers of pectenotoxins and an LC/ESI-MS/UV photodiode array method for the analysis of flavonoid glycosides. A method to measure internal nucleoside triphosphate pools of lactococci that uses formic acid in the chromatographic separation has been described. The use of formic acid in the separation and detection of intact proteins by reversed-phase LC/ESI-MS by flow injection analysis has been reported.
Key Applications: Reducing agent
Application Areas: Pharmaceuticals
Product Type: Inorganics
Chemical Class: Acids
Density: 1.22 g/cm3 at 20°C, 1.22 g/mL at 25°C (Lit.)
Viscosity: 1.784 cP. at 20°C (Lit.)
Auto Ignition: 480°C (DIN 51794)
Boiling Point: ca. 101°C at 1013 hPa (Lit.)
Melting Point: 8.2-8.4°C(lit.)
Vapor Density: 1.6 (air = 1)(Lit.)
Vapor Pressure: 42 hPa at 20°C (Lit.)
Refractive Index: n20/D 1.370 (Lit.)
pKa: 3.75 at 20°C (Lit.)
Dielectric Constant: 57.9 at 20°C (Lit.)
NOTES: Surface tension (20°C): 37.67 dyn/cm (Lit.), Heat of fusion (100°C): 3031 cal/mole (Lit.), Heat of vaporization (100°C): 104 cal/g (Lit.)
Solubility: Miscible with water, ether, acetone, ethyl acetate, methanol, ethanol. Partially soluble in benzene, toluene, xylenes.
Storage & Handling: Room Temperature, desiccate