Synonym: γ-L-Glutamyl-L-cysteinyl-glycine, L-Glutathione reduced, GSH
CAS Number: 70-18-8
Linear Formula: H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Molecular Weight: 307.32
Beilstein Registry Number: 1729812
MDL Number: MFCD00065939
Amino Acid Sequence
γ-Glu-Cys-Gly
Application
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Biochem/physiol Actions
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
General Description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Form: crystalline powder
MP: 192-195 °C (dec.)(lit.)