IP-10, CXCL10, rat: γ-Interferon Inducible Protein 10 (IP-10)/CXCL10 was originally identified as an IFN-γ-inducible gene in monocytes, fibroblasts, and endothelial cells.
It has since been shown that IP-10 mRNA is also induced by LPS, IL-1β, TNF-α, IL-12 and viruses.
Additional cell types that have been shown to express IP-10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells.
IP-10 is also expressed in psoriatic and lepromatous lesions of skin.
The mouse homologue of human IP-10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human IP-10.