Nesfatin-1, human: Nesfatin-1 is a naturally occurring protein molecule produced by the brains of mammals.
Excess nesfatin-1 in the brain leads to a loss of appetite, less frequent hunger, a 'sense of fullness', and a drop in body fat and weight.
A lack of nesfatin-1 in the brain leads to an increase of appetite, more frequent episodes of hunger, an increase of body fat and weight, and the inability to 'feel full.'