IL-2, Interleukin-2, porcine: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.
It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils.
IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response.
The receptor for IL-2 consists of three subunits (55 kDa IL2Rα, 75 kDa IL2Rβ, 64 kDa common gamma chain γc/IL2Rγ) that are present on the cell surface in varying preformed complexes.
Recombinant porcine IL-2 is a 15.3 kDa protein containing 134 amino acid residues and it shares about 72 % amino acid sequence identity with mouse, human and rat IL-2.
It also shares 60 % and 67 % acid sequence identity with rhesus macaque and equus caballus IL-2, respectively., UnitProt ID: P26891