Epitope: Binds to N-terminal amino acids 16-25 of wild-type and mutant p53
Host: Mouse, clone BP53-12
Species Reactivity: (+) Human p53
Application(s): FC, ICC, IHC (paraffin-embedded sections), and WB
Cellular p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (DNA damage, hypoxia, heat shock, etc.) and acts to prevent further proliferation of the stressed cell by induction of cell cycle arrest or apoptotic mediators.