Antigen: purified human recombinant PCSK9
Host: mouse, clone 15A6
Isotype: IgG1
Cross Reactivity: (+) human recombinant PCSK9
Application(s): PCSK9 ligand blotting (nondenaturing conditions) and WB
PCSK9 is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism. Gain-of-function mutations in the PCSK9 gene are associated with autosomal dominant hypercholesterolemia which is characterized by an increase in low-density lipoprotein (LDL) cholesterol levels.