Antigen: full-length recombinant human HMGB1
Host: mouse, clone IMG19N12A1
Isotype: IgG1k
Cross Reactivity: (+) human and mouse HMGB1
Application: WB
HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).