Antigen: human caspase-8 amino acids PVETDSEEQP
Host: mouse, clone 90A992
Cross Reactivity: (+) human, chimpanzee, and Rhesus monkey caspase-8
Application(s): FC, IHC (paraffin-embedded tissue), and WB
Caspase-8 forms a direct link between the activation of CD95 and the caspase pathway. Overexpression of caspase-8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family.