Antigen: recombinant full-length human caspase-3
Host: mouse, clone 31A1067
Cross Reactivity: (+) human, mouse, and rat caspase-3
Application(s): IHC (frozen and paraffin-embedded sections) and WB
Caspase-3 cleaves the death substrate PARP to a specific 85 kDa form observed during apoptosis and is inhibitable by the CrmA protein. Other caspase-3 substrates include DNA-PK, actin, GAS2, procaspase-6, etc.