Cellomics Technology

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Cellomics Technology

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  • HPSE shRNA lentivirus

    Cellomics Technology

    Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. Heparanase (HPSE) is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. HPSE is critical regulator of angiogenesis and…

  • CMV-RFP lentivirus

    Cellomics Technology

    TurboRFP is a red (orange) fluorescent protein (ex. 553 and em. 574 nm) derived from sea anemoneEntacmaea quadricolor [Merzlyak et al., 2007]. Possessing high photostability and pH stability, TurboRFP is more than twice brighter than DsRed2. Fast TurboRFP maturation makes it clearly detectable in…

  • CMV-Renilla luciferase lentivirus

    Cellomics Technology

    Luciferase is an enzyme that is catalyzes the oxidation of luciferin to generate bioluminescence. Renilla luciferase refers to the enzyme that was isolated from the sea pansy, Renilla reniformis. Included Fees: C839R85 & C839R86 have a Dry Ice Fee included in the list price.

  • CHI3L1 shRNA lentivirus

    Cellomics Technology

    In humans, CHI3L1 encodes Chitinase-3-like protein 1 (CHI3L1) that a glycoprotein member of the glycosyl hydrolase 18 family. It is a secreted glycoprotein and catalyzes the hydrolysis of chitin glycopolymer found in insect exoskeletons and fungal cell walls. The protein lacks chitinase activity…

  • Calcium indicator GCaMP3 lentivirus (CMV)

    Cellomics Technology

    Calcium is a universal second messenger regulating essential cellular signaling events in a broad range of tissues and organisms. GCaMP3 is a fusion calcium indicator of green fluorescent protein (GFP), calmodulin and the M13 domain of a myosin light chain kinase designed to show the calcium ion…

  • Inducible tet-on GFP lentivirus

    Cellomics Technology

    Green fluorescent protein (GFP), a 27 kDa protein derived from the jellyfish Aequorea victoria, emits green light (emission peak at a wavelength of 509 nm) when excited by blue light (excitation peak at a wavelength of 395 nm). Green Fluorescent Protein (GFP) has become an invaluable tool in cell…

  • Inducible tet-on Nrl lentivirus

    Cellomics Technology

    The basic motif-leucine zipper transcription factor NRL (neural retina leucine zipper) is essential for rod photoreceptor specification in the mammalian retina. This lentivirus expresses human Nrl under the control of the Tet promoter. Included Fees: C839Q75 & C839Q76 have a…

  • Inducible tet-on miR-183 lentivirus

    Cellomics Technology

    It has been observed that microRNA miR-183 plays an important role in tumorigenesis and cancer metastasis. This lentivirus expresses miR-183 under the control of the Tet promoter. Included Fees: C839Q57 & C839Q58 have a Dry Ice Fee included in the list price.

  • EF1A-NANOG_m lentivirus

    Cellomics Technology

    NANOG is a transcription factor important for maintaining the self-renewal capacity of undifferentiated stem cells. Ectopic expression of NANOG has been used to generate iPS cells in culture. Human elongation factor-1 alpha (EF-1 alpha) is a constitutive promoter of human origin that can be used…

  • Set of lentivirus (Tet-driven SOX2, OCT3/4, KLF4 and C-MYC)

    Cellomics Technology

    This set contains four Tet-driven vectors: KLF4 (PLV-10026), SOX2 (PLV-10027), C-MYC (PLV-10028), and OCT3/4 (PLV-10019). Included Fees: C839T47 & C839T48 have a Dry Ice Fee included in the list price.

  • PGK-Cre, CMV-Renilla luciferase lentivirus

    Cellomics Technology

    Cre Recombinase is a tyrosine recombinase enzyme derived from the P1 Bacteriophage. The enzyme uses a topoisomerase I like mechanism to carry out site specific recombination events. The enzyme (38kDa) is a member of the Integrase family of site specific recombinase and it is known to catalyse the…

  • EF1A-GFP lentivirus

    Cellomics Technology

    Green fluorescent protein (GFP), a 27 kDa protein derived from the jellyfish Aequorea victoria, emits green light (emission peak at a wavelength of 509 nm) when excited byblue light (excitation peak at a wavelength of 395 nm). Green Fluorescent Protein (GFP) has become an invaluable tool in cell…

  • Calcium indicator GCaMP3 lentivirus (CAG)

    Cellomics Technology

    Calcium is a universal second messenger regulating essential cellular signaling events in a broad range of tissues and organisms. GCaMP3 is a fusion calcium indicator of green fluorescent protein (GFP), calmodulin and the M13 domain of a myosin light chain kinase designed to show the calcium ion…

  • Inducible tet-on FOXD1 lentivirus

    Cellomics Technology

    Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 plays a dual role in the establishment of the binocular visual pathways: specification of the ventrotemporal (VT) retina, and patterning of the developing ventral diencephalon…

  • Inducible tet-on OTX2 lentivirus (Puro)

    Cellomics Technology

    OTX2 is a homeodomain transcription factor and one of the key regulator genes of photoreceptor formation. This lentivirus expresses human OTX2 under the control of the Tet promoter. Included Fees: C839Q81 & C839Q82 have a Dry Ice Fee included in the list price.

  • PGK-GFP lentivirus

    Cellomics Technology

    Green fluorescent protein (GFP), a 27 kDa protein derived from the jellyfish Aequorea victoria, emits green light (emission peak at a wavelength of 509 nm) when excited byblue light (excitation peak at a wavelength of 395 nm). Green Fluorescent Protein (GFP) has become an invaluable tool in cell…

  • STAT3 Firefly luciferase reporter lentivirus (Puro)

    Cellomics Technology

    This STAT3 reporter lentivirus expresses Firefly luciferase under the control of a minimal (m)CMV promoter and tandem repeats of the STAT3 transcriptional response element (TRE). It can be used to monitor the transcriptional activity of STAT3. Included Fees: C839R71 & C839R72 have a…

  • CMV-MAD2 lentivirus

    Cellomics Technology

    MAD2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2 was showed to be associated with tumor differentation. This lentivirus express human MAD2 under the control of the CMV promoter.…

  • ADAM-17 shRNA lentivirus

    Cellomics Technology

    ADAM-17 gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM-17 is an…

  • Inducible tet-on Smad6 lentivirus

    Cellomics Technology

    Smad6 and Smad7 are inhibitory Smads induced by transforming growth factor β-Smad signal transduction pathways in a negative-feedback mechanism. Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube. Smad6 is also involved in multiple tissue differentiation…

  • CMV-OCT3/4 lentivirus

    Cellomics Technology

    OCT3/4 (POU5F1) is a transcription factor that is expressed in stem cells and germ cells. Its expression is required to sustain cell self-renewal of undifferentiated stem cells. Oct-3/4 is the most recognized marker for totipotent ES cells. Ectopic expression of OCT3/4 has been used to produce iPS…

  • Inducible tet-on SOX9 lentivirus

    Cellomics Technology

    SOX9 is a transcription factor essential for multipotent neural stem cell (NSC) formation and maintenance. Sox9 is a major molecular component of the neuron–glia switch in the developing spinal cord. SOX9 also plays a key role in chondrogenesis. This lentivirus expresses human SOX9 under the…

  • hTERT lentivirus (CMV, Puro)

    Cellomics Technology

    Telomerase reverse transcriptase (TERT, or hTERT in human) is a catalytic subunit of the enzyme telomerase, Ectopic expression of telomerase in telomerase-silent cells is sufficient to overcome senescence and to extend cellular lifespan, and has been used for cell immortalization. This lentivirus…

  • Inducible tet-on miR-182 lentivirus

    Cellomics Technology

    It has been observed that microRNA miR-182 plays a role in tumorigenesis and cancer metastasis. This lentivirus expresses miR-182 under the control of the Tet promoter. Included Fees: C839Q55 & C839Q56 have a Dry Ice Fee included in the list price.

  • Inducible tet-on SOX2 lentivirus

    Cellomics Technology

    SRY (sex determining region Y)-box 2 (SOX2) is a transcription factor critical for maintaining the self-renewal capacity of undifferentiated stem cells. Ectopic expression of SOX2 has been used to produce iPS cells in culture. This lentivirus expresses Sox2 under the control of the Tet promoter. …

  • EF1A-LIN28 lentivirus

    Cellomics Technology

    LIN28 is a microRNA-binding protein that has been shown to bind the let-7 pre-microRNA and block production of mature let-7 in embryonic stem cells. This activity appears to preserve undifferentiated state of stem cells. Subsequently, LIN28 expression has been used to generate iPS cells. Human…

  • Inducible tet-on ASCL1 lentivirus

    Cellomics Technology

    ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) is a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding.…

  • Inducible tet-on PRDM1 lentivirus

    Cellomics Technology

    PR domain containing 1 with zinc finger domain (PRDM1)/B lymphocyte–induced maturation protein 1 (BLIMP1) is a transcriptional repressor. PRDM1 plays fundamentally important roles in many cell lineages and in the early development of several cell types, including B and T lymphocytes, germ…

  • CMV-RAX lentivirus

    Cellomics Technology

    RAX (Retina And Anterior Neural Fold Homeobox) is a homeobox-containing transcription factor that functions in eye development. RAX is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in…

  • Set of lentivirus (CMV-driven SOX2, OCT3/4, KLF4 and C-MYC)

    Cellomics Technology

    This set contains four CMV-driven vectors: SOX2 (PLV-10008), OCT3/4 (PLV-10007), KLF4 (PLV-10006) and C-MYC (PLV-10005). Included Fees: C839T43 & C839T44 have a Dry Ice Fee included in the list price.

  • Inducible tet-on OSKM lentivirus

    Cellomics Technology

    Induced pluripotent stem (iPS) cells can be generated from differentiated somatic cells by over-expressing a set of specific transcription factors called reprogramming factors. Typically four reprogramming factors are chosen, Oct4, Sox2, Klf4 and c-Myc (OSKM), which are introduced into the target…

  • CMV-MITF-A lentivirus

    Cellomics Technology

    MITF-A is an isoform of MITF (microphthalmia-associated transcription factor), a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible…

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