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Enzo Life Sciences Signal Transduction

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  • Bapta, Free Acid

    Enzo Life Sciences

    97%, MW=476.4 [85233-19-8] Storage: -20°C 1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid. BAPTA is a Ca 2+ chelator with 105-fold greater affinity for Ca 2+ than for Mg 2+ 1,2 . BAPTA, free acid is not cell permeable and therefore is useful as an extracellular calcium…

  • PD-98059, 5 mg

    Enzo Life Sciences

    >95%, MW=267.3 [167869-21-8] Storage: -20°C PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase 1,2 . PD-98059 is cell permeable. In PC12…

  • Protein Tyrosine Phosphate, 50 ug

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=37.4 kDa Storage: -70°C Human protein tyrosine phosphatase (residues 1-322), expressed in E. coli. PTP1B is the ubiquitous, prototypical nontransmembrane PTP originally identified in human placenta 1,2 . Useful for the study of tyrosine phosphatase kinetics,…

  • HDAC Fluorimetric Assay / Drug Discovery Kit - A F

    Enzo Life Sciences

    No Radioactivity No Extractions HTS Friendly-Mix and Read on One 96-well Plate For Class I and Class II HDACs and Sirtuins Applications Include Cell-Based Assays and Assay of Immunoprecipitates Histone deacetylase inhibitors have shown promise as anti-tumor agents and…

  • MIT-E-PSI Mitochondrial Permeability Kit

    Enzo Life Sciences

    The Mit-E-ψ ™ Kit detects the change in mitochondrial permeability which is an early indication of the initiation of cellular apoptosis. The resulting change in membrane potential, (Δ ψ ) can be detected by a unique fluorescent cationic dye,…

  • Myristoylated PKCz Peptide Inhibitor, 0.5 mg

    Enzo Life Sciences

    N-Myristoyl-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu >97%, MW=1928.2, Storage: -20°C Pseudosubstrate sequence from human PKCζ 1 ,2 (113-125) completely conserved in rabbit, rat, mouse and Xenopus. Sequence is also identical in human PKCι (114-126) and mouse…

  • Caspase-11, 5000 U

    Enzo Life Sciences

    >90% by SDS-PAGE, MW=23 + 10 kDa subunits Storage: -80°C Produced by expression of a mouse cDNA in E. coli. The cDNA encodes residues identical to Pro-81 to Asn-373 (C-terminus) at Genbank accession #Y13089. One unit hydrolyzes 1 pmol/min of Ac-WEHD-pNA (500 M) at 30C. A member…

  • Caspase-6, 5000 U

    Enzo Life Sciences

    >80% by SDS-PAGE, MW=18 + 11 kDa Storage: -80°C Highly active caspase-6 (Mch2) from human cDNA, expressed in an E. coli expression system. One U=1 pmol/min at 30°C using Ac-VEID-pNA as substrate. 1. K. Ort et al., "J. Biol. Chem." 1996, 271: 16443 2. Y. Emoto et…

  • EGF Receptor, 10 U

    Enzo Life Sciences

    (Matrix Metalloproteinase-12, Metalloelastase, Macrophage Elastase) Storage: -70°C MMP-12 catalytic domain (residues 84-255) from human cDNA, expressed in E. coli. Applications: study enzyme kinetics, cleave target substrates, and screen for inhibitors.

  • Trichostatin A, 1 mg

    Enzo Life Sciences

    99%, MW=302.4 [58880-19-6] Storage: -20°C Trichostatin A (TSA) is a potent and reversible inhibitor of histone deacetylase. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin 1 . In cells latently infected with…

  • 5-Iodotubercidin

    Enzo Life Sciences

    98%, MW=392.2 [24386-93-4] Storage:-20°C Inhibits ERK2 (Ki= 525nM) 1 . also inhibits adenosine kinase (Ki= 30nM) CK1 and CK2 and insulin receptor kinase 2 . 1. T. Fox et al, "Protein Sci." 1998, 7: 2249 2. D. Massillon et al., "Biochem. J." 1994, 299: 123

  • Rapamycin

    Enzo Life Sciences

    98%, MW=914.2 [53123-88-9] Storage: -20°C Rapamycin is one member of a family of macrolide immunosuppressants which bind to and inhibit the FK506 binding protein (FKBP) proline rotamase 1 . Rapamycin is bound simultaneously by FKBP12 and FRAP (FKBP12-Rapamycin-Associated-Protein) 2 . FRAP…

  • Ag-825

    Enzo Life Sciences

    98%, MW=397.5, Storage: RT 5-[(Benzthiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide. A selective HER1-2 (HER2-Neu) 1 tyrosine kinase inhibitor 2 . 1. A. Levitzki et al., "Science" 1995, 267: 1782 2. H. Daub et al., "Nature" 1996, 379: 559

  • Biomol Green Reagent

    Enzo Life Sciences

    The BIOMOL GREEN™ Reagent is a convenient, 1-step reagent for measuring the free phosphate released during enzymatic phosphatase assays. It is a modification of the classic Malachite green reagent 1,2 and it offers the following advantages: Non-Radioactive Convenient one-step…

  • 4-Phorbol 12-Myristate 13-Acetate (Pma)

    Enzo Life Sciences

    99%, MW=616.8 [63597-44-4] Storage: -20°C Negative control for phorbol 12-myristate 13-acetate (PMA).

  • Ly 294002

    Enzo Life Sciences

    2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99%, MW=307.4 [154447-36-6] Storage: -20°C LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase). In in vitro assays using purified PI 3-kinase, LY 294002 displays an IC50

  • Ubiquitinylation (Ubiquitin Conjugation) Kit, 50 Assays

    Enzo Life Sciences

    Store at -80°C This kit provides the means of generating a range of thioester-linked ubiquitin conjugation enzymes (E2s), utilizing the first two steps in the ubiquitin cascade; for use in the transfer of ubiquitin to E3 ligases; and the subsequent ubiquitinylation of target substrate…

  • Caspase-3, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=17 + 12 kDa Storage: -80°C Highly active caspase-3 (CPP32; Yama; apopain) from human cDNA, expressed in an E. coli expression system 1-3 . The enzyme is cleaved and activated from the proenzyme. Specific activity is ~1 µmol/min/mg at 30°C using…

  • Caspase-7, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=20 + 12 kDa Storage: -80°C Caspase -7 1,2 is an effector caspase 3,4 in apoptosis with similar substrate preferences to caspase-3. Like caspase-3, it can cleave PARP-1 5-7 . It displays an affinity for ADP-ribose polymers and automodification of PARP-1…

  • PY20 Agarose Beads, 0.5 mL

    Enzo Life Sciences

    Storage: 4°C Anti-phosphotyrosine, clone PY20, covalently coupled to 4% cross-linked agarose beads This product is optimized for binding of phosphotyrosine containing proteins with minimal non-specific binding. Supplied as a 50% slurry (1 ml total volume) at a conjugation ratio of…

  • Granzyme B, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=25.4 kDa Storage: -80°C Produced by expression of a human cDNA encoding residues identical to Ile-21 to Tyr-247 (C-terminus) at Genbank accession # NM004131. One unit hydrolyzes 1 pmol/min. of Ac-IEPD-pNA (200 µM) at 30°C. A serine protease with…

  • Wortmannin

    Enzo Life Sciences

    98%, MW=428.4 [19545-26-7] Storage: -20°C Wortmannin, a fungal metabolite, is a potent and selective inhibitor of phosphatidylinositol 3-kinase 1 . It is active in purified preparations and cytosolic fractions (IC50=5 nM) and is highly cell permeable. It inhibits fMLP…

  • Caspase-2, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=19 + 12 kDa Storage: -80°C The caspase-2 proenzyme includes a CARD (Caspase Recruitment Domain) in its long N-terminal prodomain 1,2 . It can associate with TNF receptor-1 in a copmlex compromising the adaptor proteins RAIDD (CRADD) and TRADD and RIP Kinase …

  • Anti-Cyclophilin A, 100 ug

    Enzo Life Sciences

    Storage: -80°C. Upon initial thawing, aliquot into smaller portions. Avoid freeze/thaw cycles. Rabbit polyclonal antibody Immunogen: Recombinant human cyclophilin A conjugated to KLH Supplied as serum Recognizes human, rat, and mouse cyclophilin A 18 kDa protein. The…

  • RII Phosphopeptide, Calcineurin Substrate, 500 ug

    Enzo Life Sciences

    Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-pSer-Val-Ala-Ala-Glu >97%, MW=2192.0, Storage: -20°C Sequence is from cAMP-dependent protein kinase (PKA) regulatory subunit type II (RII), but with a phosphoserine at Ser-95. This peptide can be used directly as a calcineurin…

  • Anti-Histone Deacetylase 2, 100 ug

    Enzo Life Sciences

    Rabbit polyclonal antibody Immunogen: C-terminal human HDAC2 (475-488) Supplied as epitope affinity purified IgG with 1 mg/ml BSA and 0.05% sodium azide in PBS. Recognizes human HDAC2 (approximately 55 kDa). Applications: Western Blot 1/2000, Immunoprecipitation.

  • MMP-12 Fluorescent Assay Kit, For Drug Discovery

    Enzo Life Sciences

    A QuantiZyme™ Assay System. The MMP-12 Fluorescent Assay Kit for Drug Discovery is a complete assay system designed to measure protease activity of matrix metalloproteinase-12 (MMP-12, metalloelastase, macrophage elastase) using a quenched fluorescent peptide: OmniMMP™ fluorescent…

  • Phorbol 12-Myristate 13-Acetate (PMA), 1 mg

    Enzo Life Sciences

    (12-tetradecanoyl phorbol 13-acetate, TPA) 99%, MW=616.8 [16561-29-8] Storage: -20°C PKC activator 1,2 (10-100 ng/ml). 1. M. Castagna et al., "J. Biol. Chem." 1982, 257: 7847   2. W.J. Ryves et al., "FEBS Lett." 1991, 288: 5

  • U-0126

    Enzo Life Sciences

    98%, MW=380.5, Storage: RT A novel, potent and selective MEK inhibitor, MEK1 IC50=72 nM, MEK2 IC50=58 nM 1 . 1. M.F. Favata et al., "J. Biol. Chem." 1998, 273: 18623

  • Nigericin, Sodium Salt

    Enzo Life Sciences

    98%, MW=747 [28380-24-7] Storage: 0°C K + and H + ionophore. Stimulates Ca 2+ release from mitochondrial stores by disruption of membrane potential 1 . Induces rapid intracellular acidification resulting in apoptosis 2 . 1. A.E. Vercesi et. al., "J. Biol. Chem." 1993, 268: 8564  …

  • Cyclosporin A

    Enzo Life Sciences

    >98%, MW=1202.6 [59865-13-3] Storage: -20°C Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex…

  • Cyclophilin A, 100 ug

    Enzo Life Sciences

    Peptidylproline cis-trans-isomerase Human Recombinant >90% SDS-PAGE, (EC 5.2.1.8) MW=18 kDa, Storage: 4°C Expressed in E. coli. Supplied in 20 mM Tris-HCl, pH 7.8. Catalyzes the cis-trans-isomeration of X-Pro-peptide bonds. Protein folding which is limited by the isomeration…

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