Enzo Life Sciences

Signal Transduction, Enzo Life Sciences

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Enzo Life Sciences Signal Transduction

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  • Caspase-9, Caspase-9 Full Length

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=20 + 12 kDa Storage: -80°C Caspase-9 is the initiator caspase of the mitochondrial/Apaf-1 apoptosis induction pathway 3-6 . This active caspase-9 (ICE-LAP-6; Mch6) is made from a human cDNA, expressed in E. coli. cDNA encodes residues identical to Ile-131 to…

  • HDAC Fluorimetric Assay / Drug Discovery Kit - A F

    Enzo Life Sciences

    No Radioactivity No Extractions HTS Friendly-Mix and Read on One 96-well Plate For Class I and Class II HDACs and Sirtuins Applications Include Cell-Based Assays and Assay of Immunoprecipitates Histone deacetylase inhibitors have shown promise as anti-tumor agents and…

  • Phorbol 12-Myristate 13-Acetate (PMA), 1 mg

    Enzo Life Sciences

    (12-tetradecanoyl phorbol 13-acetate, TPA) 99%, MW=616.8 [16561-29-8] Storage: -20°C PKC activator 1,2 (10-100 ng/ml). 1. M. Castagna et al., "J. Biol. Chem." 1982, 257: 7847   2. W.J. Ryves et al., "FEBS Lett." 1991, 288: 5

  • MIT-E-PSI Mitochondrial Permeability Kit

    Enzo Life Sciences

    The Mit-E-ψ ™ Kit detects the change in mitochondrial permeability which is an early indication of the initiation of cellular apoptosis. The resulting change in membrane potential, (Δ ψ ) can be detected by a unique fluorescent cationic dye,…

  • IR9 Insulin Receptor, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-Tyr-Glu-Thr-Asp-pTyr-Tyr-Arg-Lys >97%, MW=1703.0, Storage: -20°C Phosphopeptide corresponding to the insulin receptor regulatory region. Can be used as a tyrosine phosphatase substrate 1 . 1. H. Cho et al., "Prot. Science" 1993, 2: 977

  • GO 6983

    Enzo Life Sciences

    95%, MW=442.5, Storage: -20°C PKC inhibitor. Has been shown to selectively inhibit several PKC isoenzymes (IC50= 7nM for PKCα and PKCβ ; 6nM for PKCγ ; 10nM for PKCδ ; 60nM for PKCζ ). The compound does not effectively inhibit PKCµ…

  • Phorbol 12,13-Dibutyrate

    Enzo Life Sciences

    99%, MW=504.6 [37558-16-0] Storage: -20°C PKC activator 1 (10-100 ng/ml). 1. M. Castagna et al., "J. Biol. Chem." 1982, 257: 7847

  • L-a-Phosphatidylinositol-3, 4, 5 Trisphosphate, 100 ug

    Enzo Life Sciences

    Ptdlns 3, 4, 5-P3 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-tris phosphate-7(NH3) 98%, MW=1170, Storage: -20°C Activates Ca 2+ -insensitive PKC isotypes δ , ε and η 1 . Binds to GRP1 via a PH domain 2 . 1. A.…

  • Insulin Receptor Kinase, 20 ug

    Enzo Life Sciences

    >80% by SDS-PAGE, MW=71.7 kDa Storage: -70°C GST fusion protein containing the 48 kDa cytoplasmic domain of the β -subunit of the human insulin receptor, residues 941-1343, expressed in a baculovirus expression system. Specific activity is approximately 50 nmol/min/mg at pH 7.5…

  • MMP-3 Catalytic Domain, 10 ug

    Enzo Life Sciences

    (Matrix Metalloproteinase-3, Stromelysin-1, Transin) Storage: -70°C MMP-3 catalytic domain (residues 83-255) from human cDNA, expressed in E.coli. Applications: study enzyme kinetics, cleave target substrates, and screen for inhibitors.

  • HBDDE

    Enzo Life Sciences

    97%, MW=338.4 Storage: -20°C 2,2',3,3'4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether. Inhibits PKCα ; (IC50=43 µM) and PKCγ ; (IC50=50 µM) without inhibiting the δ , β I and β II isotypes 1 . 1. Y. Kashiwada et al., "J.…

  • PY20 Biotin Conjugate, 100 ug

    Enzo Life Sciences

    Storage: 4°C Anti-phosphotyrosine, clone PY20, conjugated to fluorescein Supplied at 0.1 mg/ml IgG2b. Applications: Immunohistochemistry & Immunocytochemistry.

  • Caspase-3, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=17 + 12 kDa Storage: -80°C Highly active caspase-3 (CPP32; Yama; apopain) from human cDNA, expressed in an E. coli expression system 1-3 . The enzyme is cleaved and activated from the proenzyme. Specific activity is ~1 µmol/min/mg at 30°C using…

  • MMP-3 Fluorescent Assay Kit, For Drug Discovery

    Enzo Life Sciences

    A QuantiZyme™ Assay System. The MMP-3 Fluorescent Assay Kit for Drug Discovery is a complete assay system designed to measure protease activity of matrix metalloproteinase-3 (MMP-3, Stromelysin-1) using a quenched fluorescent peptide: OmniMMP™ fluorescent substrate…

  • Bapta, Free Acid

    Enzo Life Sciences

    97%, MW=476.4 [85233-19-8] Storage: -20°C 1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid. BAPTA is a Ca 2+ chelator with 105-fold greater affinity for Ca 2+ than for Mg 2+ 1,2 . BAPTA, free acid is not cell permeable and therefore is useful as an extracellular calcium…

  • Bapta-Am

    Enzo Life Sciences

    >90%, MW=764.7 [139890-68-9] Storage: -20°C 1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester. BAPTA is a Ca2+ chelator 1,2 with 105-fold greater affinity for Ca 2+ than for Mg 2+ 1,2 . BAPTA-AM is a cell permeable derivative which is widely used as an…

  • Wortmannin

    Enzo Life Sciences

    98%, MW=428.4 [19545-26-7] Storage: -20°C Wortmannin, a fungal metabolite, is a potent and selective inhibitor of phosphatidylinositol 3-kinase 1 . It is active in purified preparations and cytosolic fractions (IC50=5 nM) and is highly cell permeable. It inhibits fMLP…

  • Cyclosporin A

    Enzo Life Sciences

    >98%, MW=1202.6 [59865-13-3] Storage: -20°C Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex…

  • Sulfurhodamine Multi-Caspase Activity Kit

    Enzo Life Sciences

    The Sulforhodamine Multi-Caspase Activity Kit detects active caspase enzymes in living cells. Sulforhodamine (SR) labeled caspase inhibitor probes bind to active caspase enzymes in living cell systems. These inhibitors are both cell-permeable and non-cytotoxic during the time of the labeling…

  • Ubiquitinylation (Ubiquitin Conjugation) Kit, 50 Assays

    Enzo Life Sciences

    Store at -80°C This kit provides the means of generating a range of thioester-linked ubiquitin conjugation enzymes (E2s), utilizing the first two steps in the ubiquitin cascade; for use in the transfer of ubiquitin to E3 ligases; and the subsequent ubiquitinylation of target substrate…

  • PD-98059, 5 mg

    Enzo Life Sciences

    >95%, MW=267.3 [167869-21-8] Storage: -20°C PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase 1,2 . PD-98059 is cell permeable. In PC12…

  • Caspase-4, 5000 U

    Enzo Life Sciences

    >90% by SDS-PAGE, MW=19 + 10 kDa Storage: -80°C Highly active caspase-4 (Ich-2, TX, ICErel-II), from human cDNA, expressed in an E.coli expression system. cDNA encodes residues identical to Ala-105 to Asn-377 (C-term) at genbank accession # NP-001216. Used to study enzyme…

  • Caspase-11, 5000 U

    Enzo Life Sciences

    >90% by SDS-PAGE, MW=23 + 10 kDa subunits Storage: -80°C Produced by expression of a mouse cDNA in E. coli. The cDNA encodes residues identical to Pro-81 to Asn-373 (C-terminus) at Genbank accession #Y13089. One unit hydrolyzes 1 pmol/min of Ac-WEHD-pNA (500 M) at 30C. A member…

  • Caspase-3 Cellular Assay Kit PLUS - A Quantizyme

    Enzo Life Sciences

    This kit is a complete assay system for measuring caspase-3 and caspase-3-like activity (DEVDase) in cellular extracts. It includes both colorimetric and fluorogenic substrates. It is performed in a convenient 96-well format with all reagents necessary for preparing cell extracts, measuring caspase…

  • IR5,9,10, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-pTyr-Glu-Thr-Asp-pTyr-pTyr-Arg-Lys >97%, MW=1863.0, Storage: -20°C Substrate for protein tyrosine phosphatases 1,2 . 1. C. Ramachandran et al., "Biochemistry" 1992, 31: 4232 2. M.J. King and G.J. Sale, "FEBS Lett." 1988, 237: 137

  • c-JUN Kinase Substrate, 100 ug

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=37 kDa, Storage: -80°C This is a GST-fusion protein of the c-jun (1-79) activation domain, expressed in E. coli. It is a highly specific substrate for JNK/SAPK and is not appreciably phosphorylated by MAP kinase or by p38 kinase. It can be used as a substrate for…

  • 5-Iodotubercidin

    Enzo Life Sciences

    98%, MW=392.2 [24386-93-4] Storage:-20°C Inhibits ERK2 (Ki= 525nM) 1 . also inhibits adenosine kinase (Ki= 30nM) CK1 and CK2 and insulin receptor kinase 2 . 1. T. Fox et al, "Protein Sci." 1998, 7: 2249 2. D. Massillon et al., "Biochem. J." 1994, 299: 123

  • Caspase-10, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=17 + 12 kDa Storage: -80°C Caspase-10 is an initiator caspase, highly homologous to caspase-8, a relationship that extends to the death effector domains (DEDs) of their proforms 1,2,3 . Caspase-10 was reported to activate early in TRAIL-induced apoptosis and…

  • U-0126

    Enzo Life Sciences

    98%, MW=380.5, Storage: RT A novel, potent and selective MEK inhibitor, MEK1 IC50=72 nM, MEK2 IC50=58 nM 1 . 1. M.F. Favata et al., "J. Biol. Chem." 1998, 273: 18623

  • ZM 336372

    Enzo Life Sciences

    95%, MW=389.4, Storage: -20°C Potent and specific inhibitor of c-Raf (IC50=70 nM) in vitro. It displays no significant inhibition of 20 other protein kinases except SAPK2/p38 (IC50=2 µM) 1 . ZM 336372 induces a paradoxical activation (>100 fold) of c-Raf…

  • Caspase-5, 5000 U

    Enzo Life Sciences

    >90% by SDS-PAGE, MW=18 + 11 kDa Storage: -80°C Caspase-8 is an initiator caspase activated in the death-inducing signaling complexes (DISCs) of the TNF receptor superfamily (e.g. TRAIL, FasL, TNFα receptors) 1,2,7,9 . Highly active caspase-8 (FLICE; Mch5; MACH) from human…

  • Caspase-1, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=20 + 10 kDa Human Recombinant Storage: -80°C Highly active caspase-1 (Interleukin-1 converting enzyme; ICE) from human cDNA, expressed in E. coli. Caspase-1 is thought to be primarily involved in regulation of inflammation, specifically the proteolytic…

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