Signal Transduction

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  • Antibiotic A-23187, 10 mg

    Enzo Life Sciences

    99%, MW=523.6 [52665-69-7] Storage: -20°C A highly selective calcium ionophore 1 . Useful tool for increasing intracellular Ca 2+ concentration. 1. K. Geitzen et al., "Biochem. J." 1982, 207 541

  • Protein Kinase C Beta I, 5 ug

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=76.8 kDa, (EC 2.7.1.37) Storage: -80°C Human recombinant Highly active enzyme expressed in a baculovirus expression system. Supplied at 0.5 mg/ml in 50% glycerol/stabilizing buffer. Specific activity: ~0.9 µmol phosphate/min/mg protein using histone H1 as…

  • Biomol Green Reagent

    Enzo Life Sciences

    The BIOMOL GREEN™ Reagent is a convenient, 1-step reagent for measuring the free phosphate released during enzymatic phosphatase assays. It is a modification of the classic Malachite green reagent 1,2 and it offers the following advantages: Non-Radioactive Convenient one-step…

  • L-a-Phosphatidylinositol-3, 4, 5 Trisphosphate, 100 ug

    Enzo Life Sciences

    Ptdlns 3, 4, 5-P3 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-tris phosphate-7(NH3) 98%, MW=1170, Storage: -20°C Activates Ca 2+ -insensitive PKC isotypes δ , ε and η 1 . Binds to GRP1 via a PH domain 2 . 1. A.…

  • Myristoylated PKCz Peptide Inhibitor, 0.5 mg

    Enzo Life Sciences

    N-Myristoyl-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu >97%, MW=1928.2, Storage: -20°C Pseudosubstrate sequence from human PKCζ 1 ,2 (113-125) completely conserved in rabbit, rat, mouse and Xenopus. Sequence is also identical in human PKCι (114-126) and mouse…

  • Trichostatin A, 1 mg

    Enzo Life Sciences

    99%, MW=302.4 [58880-19-6] Storage: -20°C Trichostatin A (TSA) is a potent and reversible inhibitor of histone deacetylase. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin 1 . In cells latently infected with…

  • L-a-Phosphatidylinositol-3 Phosphate, 100 ug

    Enzo Life Sciences

    Ptdlns-3-P 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3-phosphate-3NH3 98%, MW=942.1, Storage: -20°C Lipid product produced by the action of PI 3-kinase 1 . 1. R. Kapeller and L.C. Cantley, "Bioessays" 1994, 16 565

  • Granzyme B, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=25.4 kDa Storage: -80°C Produced by expression of a human cDNA encoding residues identical to Ile-21 to Tyr-247 (C-terminus) at Genbank accession # NM004131. One unit hydrolyzes 1 pmol/min. of Ac-IEPD-pNA (200 µM) at 30°C. A serine protease with…

  • Bapta, Free Acid

    Enzo Life Sciences

    97%, MW=476.4 [85233-19-8] Storage: -20°C 1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid. BAPTA is a Ca 2+ chelator with 105-fold greater affinity for Ca 2+ than for Mg 2+ 1,2 . BAPTA, free acid is not cell permeable and therefore is useful as an extracellular calcium…

  • Sb-203580

    Enzo Life Sciences

    98%, MW=377.4, Storage: -20°C 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole. Selective inhibitor of p38 mitogen-activated protein (MAP) kinase 1 . Inhibition is competitive with ATP (Ki=21 nM) 2 . Inhibits p38-MAPK stimulation of MAPKAPK2…

  • PD-98059, 5 mg

    Enzo Life Sciences

    >95%, MW=267.3 [167869-21-8] Storage: -20°C PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase 1,2 . PD-98059 is cell permeable. In PC12…

  • Ag-825

    Enzo Life Sciences

    98%, MW=397.5, Storage: RT 5-[(Benzthiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide. A selective HER1-2 (HER2-Neu) 1 tyrosine kinase inhibitor 2 . 1. A. Levitzki et al., "Science" 1995, 267: 1782 2. H. Daub et al., "Nature" 1996, 379: 559

  • GO 6983

    Enzo Life Sciences

    95%, MW=442.5, Storage: -20°C PKC inhibitor. Has been shown to selectively inhibit several PKC isoenzymes (IC50= 7nM for PKCα and PKCβ ; 6nM for PKCγ ; 10nM for PKCδ ; 60nM for PKCζ ). The compound does not effectively inhibit PKCµ…

  • Anti-Histone Deacetylase 1, 100 ug

    Enzo Life Sciences

    Rabbit polyclonal antibody Immunogen: C-terminal human HDAC1 (467-482) Supplied as epitope affinity purified IgG with 1 mg/ml BSA and 0.05% sodium azide in PBS. Recognizes human HDAC1 (approximately 62 kDa). Applications: Western Blotting 1/2000, Immunoprecipitation.

  • 5-Iodotubercidin

    Enzo Life Sciences

    98%, MW=392.2 [24386-93-4] Storage:-20°C Inhibits ERK2 (Ki= 525nM) 1 . also inhibits adenosine kinase (Ki= 30nM) CK1 and CK2 and insulin receptor kinase 2 . 1. T. Fox et al, "Protein Sci." 1998, 7: 2249 2. D. Massillon et al., "Biochem. J." 1994, 299: 123

  • Caspase-9, Caspase-9 Full Length

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=20 + 12 kDa Storage: -80°C Caspase-9 is the initiator caspase of the mitochondrial/Apaf-1 apoptosis induction pathway 3-6 . This active caspase-9 (ICE-LAP-6; Mch6) is made from a human cDNA, expressed in E. coli. cDNA encodes residues identical to Ile-131 to…

  • c-JUN Kinase Substrate, 100 ug

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=37 kDa, Storage: -80°C This is a GST-fusion protein of the c-jun (1-79) activation domain, expressed in E. coli. It is a highly specific substrate for JNK/SAPK and is not appreciably phosphorylated by MAP kinase or by p38 kinase. It can be used as a substrate for…

  • PY20 Biotin Conjugate, 100 ug

    Enzo Life Sciences

    Storage: 4°C Anti-phosphotyrosine, clone PY20, conjugated to fluorescein Supplied at 0.1 mg/ml IgG2b. Applications: Immunohistochemistry & Immunocytochemistry.

  • SUMOylation Kit, 20-50 Assays

    Enzo Life Sciences

    Store at -80°C This assay kit contains all reagents necessary for the routine detection of SUMOylation activity. A mono-SUMOylation substrate (RanGAP1) is included as a control to allow clear detection of the SUMOylation reaction. Recombinant human SUMO E1, recombinant human SUMO E2,…

  • Anti-Histone Deacetylase 3, 100 ug

    Enzo Life Sciences

    Rabbit polyclonal antibody Immunogen: C-terminal human HDAC3 (415-428) Supplied as epitope affinity purified IgG with 1 mg/ml BSA and 0.05% sodium azide in PBS. Recognizes human HDAC3 (approximately 48 kDa). Applications: Western Blot 1/2000, Immunopreciptation.

  • Caspase-6, 5000 U

    Enzo Life Sciences

    >80% by SDS-PAGE, MW=18 + 11 kDa Storage: -80°C Highly active caspase-6 (Mch2) from human cDNA, expressed in an E. coli expression system. One U=1 pmol/min at 30°C using Ac-VEID-pNA as substrate. 1. K. Ort et al., "J. Biol. Chem." 1996, 271: 16443 2. Y. Emoto et…

  • Caspase-4, 5000 U

    Enzo Life Sciences

    >90% by SDS-PAGE, MW=19 + 10 kDa Storage: -80°C Highly active caspase-4 (Ich-2, TX, ICErel-II), from human cDNA, expressed in an E.coli expression system. cDNA encodes residues identical to Ala-105 to Asn-377 (C-term) at genbank accession # NP-001216. Used to study enzyme…

  • Caspase-10, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=17 + 12 kDa Storage: -80°C Caspase-10 is an initiator caspase, highly homologous to caspase-8, a relationship that extends to the death effector domains (DEDs) of their proforms 1,2,3 . Caspase-10 was reported to activate early in TRAIL-induced apoptosis and…

  • HDAC Fluorimetric Assay / Drug Discovery Kit - A F

    Enzo Life Sciences

    No Radioactivity No Extractions HTS Friendly-Mix and Read on One 96-well Plate For Class I and Class II HDACs and Sirtuins Applications Include Cell-Based Assays and Assay of Immunoprecipitates Histone deacetylase inhibitors have shown promise as anti-tumor agents and…

  • IR5 Insulin Receptor, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-pTyr-Glu-Thr-Asp-Tyr-Tyr-Arg-Lys >97%, MW=1703.0, Storage: -20°C Phosphopeptide corresponding to the insulin receptor regulatory region. Can be used as a tyrosine phosphatase substrate 1 . 1. H. Cho et al., "Prot. Science" 1993, 2: 977

  • U-0126

    Enzo Life Sciences

    98%, MW=380.5, Storage: RT A novel, potent and selective MEK inhibitor, MEK1 IC50=72 nM, MEK2 IC50=58 nM 1 . 1. M.F. Favata et al., "J. Biol. Chem." 1998, 273: 18623

  • IR0 Insulin Receptor, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-Tyr-Glu-Thr-Asp-Tyr-Tyr-Arg-Lys >97%, MW=1622.9, Storage: -20°C Sequence is from insulin receptor β -subunit cytoplasmic domain, inclusive of regulatory autophosphorylation sites Tyr 1146, 1150 and 1151 1 . It has been used as an insulin receptor tyrosine…

  • Phorbol 12-Myristate 13-Acetate (PMA), 1 mg

    Enzo Life Sciences

    (12-tetradecanoyl phorbol 13-acetate, TPA) 99%, MW=616.8 [16561-29-8] Storage: -20°C PKC activator 1,2 (10-100 ng/ml). 1. M. Castagna et al., "J. Biol. Chem." 1982, 257: 7847   2. W.J. Ryves et al., "FEBS Lett." 1991, 288: 5

  • MIT-E-PSI Mitochondrial Permeability Kit

    Enzo Life Sciences

    The Mit-E-ψ ™ Kit detects the change in mitochondrial permeability which is an early indication of the initiation of cellular apoptosis. The resulting change in membrane potential, (Δ ψ ) can be detected by a unique fluorescent cationic dye,…

  • MMP-3 Catalytic Domain, 10 ug

    Enzo Life Sciences

    (Matrix Metalloproteinase-3, Stromelysin-1, Transin) Storage: -70°C MMP-3 catalytic domain (residues 83-255) from human cDNA, expressed in E.coli. Applications: study enzyme kinetics, cleave target substrates, and screen for inhibitors.

  • IR9 Insulin Receptor, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-Tyr-Glu-Thr-Asp-pTyr-Tyr-Arg-Lys >97%, MW=1703.0, Storage: -20°C Phosphopeptide corresponding to the insulin receptor regulatory region. Can be used as a tyrosine phosphatase substrate 1 . 1. H. Cho et al., "Prot. Science" 1993, 2: 977

  • Phorbol 12,13-Dibutyrate

    Enzo Life Sciences

    99%, MW=504.6 [37558-16-0] Storage: -20°C PKC activator 1 (10-100 ng/ml). 1. M. Castagna et al., "J. Biol. Chem." 1982, 257: 7847

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