An intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids; also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.

An isotopically enriched form of a PUFA with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.

Allicin is an thiocyanate found in garlic; it exhibits a wide variety of properties, including anticancer, antioxidative, antihypertensive, anti-arrhythmic, anti-parasitic, and anti-diabetic activities. In vitro, allicin binds cellular nucleic acid, primarily nitrogenous bases and phosphate…

A major metabolite of PGD2 found in human and mouse urine at levels of approximately 1.5 and 8.1 ng/mg creatinine, respectively.

An isotopically enriched form of a PUFA standard with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.

An analog of geldanamycin which has potent in vivo activity and reduced toxicity; has diverse anti-tumor actions; promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).

α-ESA is a conjugated PUFA commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown…

An α-sulphonated version of arachidonic acid that may possess improved lipophilicity.

A metabolite of 14,15-LTC4 and 14,15-LTD4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency compared LTC4, but approximately 100-fold greater potency than histamine.

A C-7 truncated analog of LXA4 that is equiactive as LXA2 in the inhibition of LTB4-induced neutrophil chemotaxis (IC50 = 5 nM).

An optically active isomer of TBP-OH, a compound produced from the metabolism of the organophosphorus solvent, TBP.

A unique LT with weak contractile activity on both guinea pig ileum and pulmonary parenchyma compared to 5-LO-derived LTs; increases vascular permeability of human endothelial cell monolayers with similar potency to that of 5-LO-derived LTs.

An internal standard for the quantification of dinor-OPDA by GC- or LC-MS.

LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. The rank order of potency of the…

An intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols; also serves as a donor in post-translational isoprenylation of proteins.

A PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC₅₀ = 2.5 µM); reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.

LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.

Inhibits PAD4 activity (IC50 = 21.6 μM) as well as PAD1 and PAD3 activity (IC50s = 29.5 and 350 μM, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

A selective and potent ROCK inhibitor (IC₅₀ = 11.8 nM for ROCK-II); poorly inhibits CaMKII, protein kinase G, and Aurora A (IC₅₀ = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC₅₀ ≥ 10 μM for each).

An internal standard for the quantification of acetaminophen by GC- or LC-MS.

An internal standard for the quantification of 8-iso PGE2 by GC- or LC-MS.

An aldehyde product of the oxidative deamination of dopamine that is toxic to neurons.

A prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling; may activate TRPV1 and TRPV4.

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent sEH inhibition.

A SAHA derivative with a benzophenone crosslinker and an alkyne tag to be used for profiling HDAC activities in proteomes and live cells; labels HDAC complex proteins both in proteomes at 100 nM and in live cells at 500 nM; IC50 = ~3 μM for inhibition of HDAC activity in HeLa cell nuclear…

A selective PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC₅₀ = 3.7 µM); reversibly blocks the production of glucose-derived serine in cells.

A non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.

A potent inhibitor of Nampt (IC₅₀ = 3 nM); induces cell death in the neuroblastoma cell line SH-SY5Y with an IC₅₀ value of 3.8 nM through a process that appears to involve autophagy.