LKT Labs

Biologically Active Small Molecules, LKT Labs

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LKT Labs Biologically Active Small Molecules

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  • [Tyr8]-Bradykinin

    LKT Labs

    Bradykinin is a peptide that exhibits natriuretic, antioxidative, vasodilatory, and pro-angiogenic activities. Bradykinin stimulates bradykinin receptors and increases PLC activity, decreasing ENaC open probability, inhibiting distal nephron Na+ transport, and inducing natriuresis. In vitro,…

  • L-Arginine

    LKT Labs

    L-Arginine is an endogenous amino acid also found in meat, dairy, grains, and legumes. L-Arginine exhibits vasodilatory and antihypertensive activities, as it is a precursor to the formation of NO. L-Arginine decreases systolic and diastolic blood pressure, improving cardiovascular and endothelial…

  • Bexarotene

    LKT Labs

    Bexarotene is a retinoid compound that binds and activates retinoid X receptors (RXRs) and is approved to treat cutaneous T cell lymphoma. Bexarotene displays a wide variety of beneficial activities, such as anticancer chemotherapeutic, anti-hyperlipidemic, and neuroprotective properties.…

  • Canertinib Dihydrochloride

    LKT Labs

    Canertinib is an irreversible inhibitor of EGFR (HER2/ErbB). This compound is currently in clinical trials as an anticancer chemotherapeutic, displaying activity against a variety of cancers. In a cellular model of melanoma, canertinib exhibits cytostatic activity, stopping cell growth in the G1…

  • 6-Aminocaproic Acid

    LKT Labs

    6-Aminocaproic acid is a protease inhibitor that displays anticancer activity but is limited by cytotoxicity. 6-Aminocaproic acid inhibits plasmin, preventing fibrinolysis; it may exhibit pro-thrombotic activity, as it is clinically used to treat bleeding disorders.

  • Ciprofloxacin

    LKT Labs

    Ciprofloxacin is a second generation fluoroquinolone antibiotic that exhibits antibacterial activity against both gram negative and gram positive bacteria. Ciprofloxacin inhibits DNA gyrase and topoisomerase IV, preventing DNA replication.

  • L-Citrulline

    LKT Labs

    L-Citrulline is a by product of NO formation from metabolism of L-arginine that exhibits tocolytic and antioxidative activities. L-Citrulline was originally found in watermelon. In isolated rat uteri, L-citrulline decreases uterine contractile force through stimulation of the NO-cGMP relaxant…

  • Amoxicillin

    LKT Labs

    Amoxicillin is a ß-lactam penicillin antibiotic that exhibits antibacterial efficacy against both gram positive and gram negative bacteria. Amoxicillin inhibits peptidoglycan polymerization through binding of penicillin binding proteins, inhibiting cell wall synthesis.

  • Caspofungin Diacetate

    LKT Labs

    Caspofungin acetate is a lipopeptide antifungal that inhibits the enzyme 1,3-ß-Glucan synthase, which synthesizes ß-glucan polymers that form fungal cell walls. Caspofungin acetate is active against a variety of Aspergillus and Candida species and unlike many antifungals, is not metabolized by the…

  • Camptothecin

    LKT Labs

    Camptothecin is a quinolone alkaloid precursor of irinotecan; it is originally produced by Camptotheca. Camptothecin exhibits anticancer chemotherapeutic activity, inhibiting topoisomerase I and inducing double-stranded DNA breaks. Camptothecin is extremely cytotoxic and only its derivatives are…

  • Chrysophanol

    LKT Labs

    Chrysophanol is an anthraquinone originally found in species of Rheum. Chrysophanol exhibits anti-inflammatory, antiviral, antibiotic, and anticancer activities. In animal models of cerebral ischemia/reperfusion, chrysophanol inhibits activation of the NALP3 inflammasome, ameliorating…

  • Bongkrekic Acid

    LKT Labs

    Bongkrekic acid is an antioxidative compound that inhibits mitochondrial respiration by preventing the mitochondrial permeability transition (MPT); it suppresses transport of ADP/ATP across the mitochondrial inner membrane, decreasing oxidative stress. Grade: ≥98%

  • BX-795

    LKT Labs

    BX-795 inhibits PDK1, exhibiting anticancer chemotherapeutic activity. BX-795 inhibits Akt signaling, inducing apoptosis and suppressing tumor growth. Grade: ≥98%

  • 4-tert-Butyl-5-Methoxycatechol

    LKT Labs

    4-Tert-butyl-5-methoxy-catechol exhibits anticancer activity, inhibiting proliferation of leukemia cells.

  • Adenine

    LKT Labs

    Adenine is a purine nucleotide base that is involved in the synthesis of RNA and DNA. Adenine also plays roles in cellular respiration as a component of ATP, NAD, and FAD. Grade: ≥98%

  • Acivicin

    LKT Labs

    Acivicin is a fermentation product of Streptomyces; it is a glutamine analog. Acivicin inhibits ?-glutamyl transferase, CTP synthetase, GMP synthetase, and FGAM synthetase, preventing purine synthesis. Acivicin exhibits anticancer and antifungal activity, although its potential chemotherapeutic…

  • Ac-GPK(Ac)-pNA, 25 mg

    LKT Labs

    Ac-IEAR-pNA is a peptide substrate used to measure activity of caspases. Grade: ≥95%

  • Ac-GPK-pNA

    LKT Labs

    Substrate used to measure caspase activity. Grade: ≥95%

  • Citrinin

    LKT Labs

    Citrinin is a mycotoxin initially produced by Penicillum, Aspergillus, and Monascus. Citrinin exhibits cytotoxic, cardiotoxic, nephrotoxic, and pro-oxidative activities. In leydig cells, citrinin inhibits testosterone production and induces caspase-mediated apoptosis. In embryos, citrinin alters…

  • Cilnidipine

    LKT Labs

    Cilnidipine is a dihydropyridine that exhibits antihypertensive, vasodilatory, antinociceptive, and nephroprotective activities. Cilnidipine acts as an antagonist at L-type and N-type voltage-gated Ca2+ channels. In subjects with hypertension, cilnidipine decreases blood pressure and urinary…

  • Aconitine

    LKT Labs

    Aconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis.…

  • Cinacalcet Hydrochloride

    LKT Labs

    Cinacalcet is an agonist at Ca2+-sensing receptors that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. This compound decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, and lowers…

  • Citreoviridin A

    LKT Labs

    Citreoviridin A is a mycotoxin found in cereal and bread grains; it exhibits pro-oxidative, anticancer chemotherapeutic, antibacterial, antifungal, and antiviral activities. In vitro, citreoviridin A increases ROS levels and decreases glutathione, inducing oxidative stress, destabilizing the…

  • Cisatracurium Besylate

    LKT Labs

    Cisatracurium is a non-depolarizing neuromuscular junction (NMJ) blocker; it binds the a-d interface of postsynaptic nicotinic acetylcholine receptors (nAChRs). Cisatracurium acts as a skeletal muscle relaxant and is an isomer of parent compound atracurium. Cisatracurium also suppresses atrial…

  • Acemetacin

    LKT Labs

    Prodrug of indomethacin, NSAID, and COX-1/2 inhibitor used to treat pain and arthritis. It also scavenges ROS and RNS.

  • Cimetidine

    LKT Labs

    Cimetidine is an antihistamine that inhibits H2 histamine receptors, exhibiting antacid and anticancer chemotherapeutic activities. Cimetidine inhibits catalase activity and also acts as an antagonist at androgen receptors. Cimetidine increases the efficacy of chemotherapeutic compounds when…

  • Ciprofloxacin Hydrochloride Monohydrate

    LKT Labs

    Ciprofloxacin is a second generation fluoroquinolone antibiotic that exhibits antibacterial activity against both gram negative and gram positive bacteria. Ciprofloxacin inhibits DNA gyrase and topoisomerase IV, preventing DNA replication.

  • Clodronate Disodium Tetrahydrate

    LKT Labs

    Clodronate is a first-generation non-nitrogen-containing bisphosphonate that is used clinically for its anti-resorptive activity. Clodronate generates formation of a non-hydrolysable ß-? ATP analog that inhibits mitochondrial ADP/ATP translocase and prevents mitochondrial oxygen consumption…

  • Adefovir

    LKT Labs

    Adefovir is an antiviral prodrug that displays immunomodulatory activity. Adefovir is an acyclonucleotide analog that inhibits viral DNA polymerase, acting as a DNA chain terminator. Adefovir is primarily used to treat hepatitis B infection, but also displays activity against retroviruses. Adefovir…

  • Citalopram Hydrobromide

    LKT Labs

    Citalopram is a selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter (SERT); citalopram is clinically used for its antidepressant and anxiolytic activities, although it may prolong the QT interval. The S-isomer of citalopram is active and is sold on its own as…

  • Cabozantinib

    LKT Labs

    Cabozantanib is an anticancer chemotherapeutic compound that has been approved to treat medullary thyroid cancer and is in clinical trials as a treatment for other types of solid tumors. Cabozantanib exerts its anticancer activity through inhibition of Met, RET, and VEGFR2, increasing apoptosis and…

  • Brompheniramine Maleate

    LKT Labs

    Brompheniramine is a halogenated antihistamine derivative of pheniramine that exhibits anticholinergic and neuromodulatory activities. Brompheniramine inhibits the H1 histamine receptor and also displays non-selective inhibition of muscarinic acetylcholine receptors (mAChRs). Brompheniramine…

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