LKT Labs

Biologically Active Small Molecules, LKT Labs

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LKT Labs Biologically Active Small Molecules

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  • Aceclofenac

    LKT Labs

    Aceclofenac is a diclofenac analog that exhibits anti-inflammatory and analgesic activities. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that somewhat selectively inhibits COX-2; it is clinically used to treat rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.…

  • Ac-IETD-pNA

    LKT Labs

    Ac-IETD-pNA is a peptide substrate used to measure activity of caspase 8. Grade: ≥95%

  • Actinomycin

    LKT Labs

    Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…

  • Acivicin

    LKT Labs

    Acivicin is a fermentation product of Streptomyces; it is a glutamine analog. Acivicin inhibits ?-glutamyl transferase, CTP synthetase, GMP synthetase, and FGAM synthetase, preventing purine synthesis. Acivicin exhibits anticancer and antifungal activity, although its potential chemotherapeutic…

  • Adrenocorticotropic Hormone (1-4)

    LKT Labs

    Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…

  • N-Acetyl-S-(N'-phenethylthiocarbamoyl)-L-cysteine

    LKT Labs

    This compound is an N-acetyl cysteine conjugate of phenethylisothiocyanate (PEITC-NAC), exhibiting anticancer chemotherapeutic and chemopreventive activities. In lung cancer and prostate cancer models, PEITC-NAC increases activation of JNK, p53, and MAPKs, inducing apoptosis, decreasing tumor…

  • N-Acetyl-D-Leucine

    LKT Labs

    N-acetyl-D-leucine is a D-amino acid that is deacylated in bacteria by d-aminoacylase enzymes. D-amino acids inhibit bacterial biofilm formation when they are incorporated into the cell wall. Compounds such as N-acetyl-D-leucine induce release of amyloid fibers that link cells together in the…

  • Acetyl-L-Carnitine

    LKT Labs

    Acetyl-L-carnitine is a derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65,…

  • Acitretin

    LKT Labs

    Acitretin is an orally bioavailable retinoid that displays anti-inflammatory activity and is used clinically to treat psoriasis. Acitretin is a metabolite of etretinate that displays more optimized pharmacokinetic parameters. This compound activates all retinoic acid receptor subtypes…

  • Acetyl-L-Carnitine Hydrochloride

    LKT Labs

    Acetyl-L-carnitine is a derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65,…

  • Acetylsalicylic Acid

    LKT Labs

    NSAID and COX-1/2 inhibitor used to decrease inflammation. It inhibits platelet aggregation and prolongs bleeding time by decreasing levels of thromboxane A2. Chronic administration decreases risk of cancer and cardiovascular events.

  • N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine

    LKT Labs

    This compound is a conjugate of N-acetyl-cysteine and sulforaphane. Like other isothiocyanates (ITCs), this compound likely displays antioxidative activity. Grade: ≥98%

  • Acarbose

    LKT Labs

    a-Glucosidase inhibitor that decreases digestion of complex carbohydrates and prevents glucose absorption. It improves insulin sensitivity and decreases postprandial hyperglycemia.

  • Ac-IEAR-pNA

    LKT Labs

    Ac-IEAR-pNA is a peptide substrate used to measure activity of caspases. Grade: ≥95%

  • Ac-GPK(Ac)-pNA, 25 mg

    LKT Labs

    Ac-IEAR-pNA is a peptide substrate used to measure activity of caspases. Grade: ≥95%

  • Abamectin

    LKT Labs

    F0F1-ATPase and adenine nucleotide translocator inhibitor and GABA receptor antagonist. It prevents mitochondrial respiration and decreases sperm count and motility. Grade: ≥70%

  • Abacavir Sulfate

    LKT Labs

    Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection. Grade: ≥98%

  • Acipimox

    LKT Labs

    Acipimox is a niacin derivative that acts as an anti-hyperlipidemic. Acipimox decreases levels of triglycerides, LDL, and free fatty acids, and increases levels of HDL. Acipimox decreases cAMP levels and AMPK activity, suppressing lipolysis by lipase. Grade: ≥98%

  • Ac-GPK-pNA

    LKT Labs

    Substrate used to measure caspase activity.

  • Ac-D-E

    LKT Labs

    Mast cell stabilizer used to treat seasonal allergic rhinitis.

  • A66

    LKT Labs

    Inhibitor of p110a PI3K. It decreases viability of endometrial cancer cells and impairs glucose and insulin tolerance.

  • 4-bromo-A23187

    LKT Labs

    Non-fluorescent halogenated A23187 analog and Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acros

  • D,L-1'-Acetoxychavicol Acetate

    LKT Labs

    TRPA1 channel agonist and xanthine oxidase inhibitor. It increases levels of phase II enzymes in models of colon carcinogenesis and suppresses tumor growth in animal models of squamous cell carcinoma. In other cancer models, it prevents angiogenesis an

  • Abiraterone

    LKT Labs

    Progesterone derivative and Cyp17A1 inhibitor used to treat castration-resistant prostate cancer. It decreases androgen production and may inhibit eIF4F signaling.

  • Abacavir

    LKT Labs

    Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection.

  • Acemetacin

    LKT Labs

    Prodrug of indomethacin, NSAID, and COX-1/2 inhibitor used to treat pain and arthritis. It also scavenges ROS and RNS.

  • BAM-22P

    LKT Labs

    κOR and µOR agonist and cleavage product of proenkephalin.

  • 15-Acetoxyscirpenol

    LKT Labs

    Mycotoxin found in Fusarium. It induces apoptosis in Jurkat T cells.

  • ABT-199

    LKT Labs

    BH3 mimetic and Bcl-2 inhibitor. It induces apoptosis in chronic lymphocytic leukemia cells

  • BAM-12P

    LKT Labs

    Bovine adrenal medulla 12 peptide (BAM-12P) is a cleavage product of proenkephalin that binds κ-opioid receptors (κORs). BAM-12P plays a role in antinociceptive signaling.

  • A23187 Ca-Mg

    LKT Labs

    Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acrosome reaction in spermatozoa.

  • 17-Allylaminogeldanamycin

    LKT Labs

    Geldanamycin derivative and HSP90 inhibitor. It induces apoptosis in cancer cells and inhibits replication of cytomegalovirus.

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