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Biologically Active Small Molecules

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  • 4-bromo-A23187

    LKT Labs

    Non-fluorescent halogenated A23187 analog and Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acros

  • Acarbose

    LKT Labs

    a-Glucosidase inhibitor that decreases digestion of complex carbohydrates and prevents glucose absorption. It improves insulin sensitivity and decreases postprandial hyperglycemia.

  • Abacavir Sulfate

    LKT Labs

    Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection.

  • D,L-1'-Acetoxychavicol Acetate

    LKT Labs

    TRPA1 channel agonist and xanthine oxidase inhibitor. It increases levels of phase II enzymes in models of colon carcinogenesis and suppresses tumor growth in animal models of squamous cell carcinoma. In other cancer models, it prevents angiogenesis an

  • Abacavir

    LKT Labs

    Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection.

  • Acetylsalicylic Acid

    LKT Labs

    NSAID and COX-1/2 inhibitor used to decrease inflammation. It inhibits platelet aggregation and prolongs bleeding time by decreasing levels of thromboxane A2. Chronic administration decreases risk of cancer and cardiovascular events.

  • Abiraterone

    LKT Labs

    Progesterone derivative and Cyp17A1 inhibitor used to treat castration-resistant prostate cancer. It decreases androgen production and may inhibit eIF4F signaling.

  • A66

    LKT Labs

    Inhibitor of p110a PI3K. It decreases viability of endometrial cancer cells and impairs glucose and insulin tolerance.

  • Acemetacin

    LKT Labs

    Prodrug of indomethacin, NSAID, and COX-1/2 inhibitor used to treat pain and arthritis. It also scavenges ROS and RNS.

  • BAM-22P

    LKT Labs

    κOR and µOR agonist and cleavage product of proenkephalin.

  • 15-Acetoxyscirpenol

    LKT Labs

    Mycotoxin found in Fusarium. It induces apoptosis in Jurkat T cells.

  • ABT-199

    LKT Labs

    BH3 mimetic and Bcl-2 inhibitor. It induces apoptosis in chronic lymphocytic leukemia cells

  • Abamectin

    LKT Labs

    F0F1-ATPase and adenine nucleotide translocator inhibitor and GABA receptor antagonist. It prevents mitochondrial respiration and decreases sperm count and motility.

  • BAM-12P

    LKT Labs

    Bovine adrenal medulla 12 peptide (BAM-12P) is a cleavage product of proenkephalin that binds κ-opioid receptors (κORs). BAM-12P plays a role in antinociceptive signaling.

  • A23187 Ca-Mg

    LKT Labs

    Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acrosome reaction in spermatozoa.

  • 17-Allylaminogeldanamycin

    LKT Labs

    Geldanamycin derivative and HSP90 inhibitor. It induces apoptosis in cancer cells and inhibits replication of cytomegalovirus.

  • A-779

    LKT Labs

    Mas antagonist that inhibits signaling by angiotensin (1-7), preventing vasodilation and insulin sensitization.

  • ABT-263

    LKT Labs

    BH3 mimetic and inhibitor of Bcl-2, Bcl-?, and Bcl-xl. It enhances the efficacy of co-administered chemotherapeutics and inhibits proliferation of chronic lymphocytic leukemia cells.

  • ABT-737

    LKT Labs

    BH3 mimetic and inhibitor of Bcl-2, Bcl-xl, and Bcl-w. It inhibits growth of acute myelogenous leukemia cells and induces apoptosis and clearance in platelets.

  • Ac-GPK-pNA

    LKT Labs

    Substrate used to measure caspase activity.

  • Ac-D-E

    LKT Labs

    Mast cell stabilizer used to treat seasonal allergic rhinitis.

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