Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Atriopeptin III

    LKT Labs

    Atriopeptin III is an analog of atrial natriuretic peptide (ANP) that exhibits vasodilatory/hypotensive and diuretic activities. In rat kidneys, atriopeptin III increases the diameter of constricted afferent arterioles, decreasing blood pressure.

  • AS-605240

    LKT Labs

    AS-605240 is an inhibitor of p110δ PI3K that exhibits anti-inflammatory, immunosuppressive, and anti-diabetic activities. In animal models, AS-605240 inhibits the development of or reverses the progression of experimental autoimmune encephalitis (EAE). AS-605240 also inhibits the development…

  • Necrostatin-7

    Cayman Chemical

    Inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM; structurally and biologically distinct from other necrostatins as it does not inhibit RIP1 kinase.

  • Amylin, rat

    LKT Labs

    Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin from pancreatic ß-cells. Amylin is an endogenous peptide hormone that exhibits gastrointestinal motility modulating activity, decreasing gastric emptying and suppressing gastric acid secretion; these…

  • Arachidonoyl p-Nitroaniline

    Cayman Chemical

    ApNA is one of several nitroaniline fatty acid amides which can be used to measure FAAH activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate AEA (Item No. 90050). It also will hydrolyze…

  • Primary Eicosanoid HPLC Mixture

    Cayman Chemical

    This mixture contains the primary COX products produced by most mammalian tissues. Contents: Prostaglandin D2, Prostaglandin E2, 6-keto Prostaglandin F1α, Prostaglandin F2α, and Thromboxane B2 (100 µg each).

  • Adrenomedullin (13-52), human

    LKT Labs

    Adrenomedullin is an endogenous peptide hormone involved in growth and differentiation of stem cells. This peptide exhibits vasodilatory, natriuretic, and cardioprotective activities. Adrenomedullin decreases blood pressure and increases neovascularization. This peptide binds microtubule-associated…

  • Asiaticoside

    LKT Labs

    Asiaticoside is a triterpene found in Centella that exhibits anti-inflammatory, neuroprotective, cognition enhancing, antipyretic, antioxidative, pro-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. Asiaticoside inhibits melanogenesis by decreasing DNA binding by MITF; as a…

  • Zeaxanthin

    Cayman Chemical

    A dietary carotenoid present in the macula region of the eye; high dietary intake correlates with reduced risk of age-related macular degeneration.

  • 1,2-Dipalmitoyl-sn-glycero-3-PC

    Cayman Chemical

    L-DPPC is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. The extent of incorporation of the enzyme γ-glutamyl transpeptidase in erythrocyte membranes was five times higher when proteoliposomes were prepared from L-DPPC as compared to control.…

  • (+)-AS 115

    Cayman Chemical

    A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in aggressive cancers from various tissues (IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e,. (+)-AS 115 and…

  • Antiestrogen Peptide

    LKT Labs

    This peptide is a 12-amino acid peptide that exhibits antiestrogen-like effects. Grade: ≥95%

  • KAPA (hydrochloride)

    Cayman Chemical

    Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized for many assay reporter applications. KAPA is a key intermediate in the biotin…

  • L-161,982

    Cayman Chemical

    A potent and selective EP4 receptor antagonist (Ki = 24 nM); reverses the anti-inflammatory action of PGE2 in LPS - activated human macrophages at 100 nM.

  • CAY10607

    Cayman Chemical

    Binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM); inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of Hsp90 client proteins, and has no effect on a variety of kinases.

  • PIK-90

    Cayman Chemical

    A potent and cell permeable PI3K inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms α, β, γ, and δ, respectively).

  • Atosiban Acetate

    LKT Labs

    Atosiban is an antagonist at oxytocin and vasopressin receptors, exhibiting tocolytic activity. Atosiban is clinically used to decrease uterine contractility in the prevention of preterm birth.

  • CCG-1423

    Cayman Chemical

    A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription; inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.

  • 16-phenoxy tetranor Prostaglandin F2a isopropyl ester

    Cayman Chemical

    A lipophilic analog of 16-phenoxy tetranor PGF2α.

  • QX-314 (bromide)

    Cayman Chemical

    A membrane-impermeant lidocaine derivative that when combined with capsaicin selectively blocks sodium channels on nociceptive neurons via the TRPV1 channel; decreases the pain response without imparting numbness or paralysis associated with other local anesthetics.

  • Artesunate

    LKT Labs

    Artesunate is a sesquiterpene lactone derived from Artemisia. Artesunate exhibits anticancer chemotherapeutic, antiviral, anti-angiogenic, and anti-parasitic activities. Artemisinins such as artesunate are best known for their antimalarial activity. Artesunate induces G0/G1 phase cell cycle arrest,…

  • ARRY-162

    LKT Labs

    ARRY-162 is an orally bioavailable noncompetitive inhibitor of MEK1/2 and ERK that shows anticancer chemotherapeutic activity. Inhibition of MEK inhibits downstream signaling by IL-1, IL-6, and TNF. ARRY-162 inhibits proliferation in melanoma, non-small-cell lung cancer (NSCLC), head/neck cancer,…

  • Aflatoxin M1

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin M1 is the hydroxylated metabolite of aflatoxin B1; it inhibits DNA synthesis and induces cell cycle arrest.

  • ent-Prostaglandin F2a

    Cayman Chemical

    Enzymatically-derived PGF2α is an optically pure compound whereas PGF2α derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGF2α is the opposite enantiomer of PGF2α. This compound can only be generated via the isoprostane pathway…

  • CAY10649

    Cayman Chemical

    A thiazolinone compound that directly inhibits 5-LO product formation in intact polymorphonuclear leukocytes and a soluble fraction of a S100 PMNL cell lysate (IC50s = 0.28 and 0.09 μM, respectively).

  • Fusarenon X

    Cayman Chemical

    A type B trichothecene mycotoxin found in cereals contaminated with certain Fusarium species.

  • Prolyl-glycyl-proline Peptide

    Cayman Chemical

    Peptide sequence: PGP PGP is a tripeptide molecule and an established biomarker for COPD and CF. PGP functions as a neutrophil chemoattractant and is derived from the proteolytic cleavage of collagen in the extracellular matrix by a multistep cascade.

  • (±)-Enterolactone

    Cayman Chemical

    Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human serum. Enterolactone and other ligans and…

  • Adenosine Triphosphate Disodium Hydrate

    LKT Labs

    Adenosine triphosphate (ATP) disodium is clinically used to inhibit reperfusion injury after myocardial infarction during percutaneous coronary intervention; it also improves left ventricular function in clinical settings. ATP itself is a coenzyme and unit of cellular energy. ATP is required for…

  • Atracurium Besylate

    LKT Labs

    Atracurium is a reversible inhibitor of acetylcholine receptors (AChRs) that acts as a non-depolarizing neuromuscular junction blocker (NMJ); it causes muscular paralysis and is clinically used as an anesthetic.

  • 6-hydroxy Chlorzoxazone

    Cayman Chemical

    6-hydroxy Chlorzoxazone is a CYP2E1 metabolite of chlorzoxazone.

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