Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • SMER28

    Cayman Chemical

    An enhancer of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases.

  • Berberine Chloride

    LKT Labs

    Berberine is an isoquinoline alkaloid found in a variety of plants, including barberry, goldenseal, Oregon grape, California poppy, and the Amur cork tree. Berberine fluoresces under ultraviolet light and is often used to stain heparin in mast cells. Berberine displays many beneficial effects,…

  • Glycerol Triarachidonoyl

    Cayman Chemical

    A polyunsaturated triacylglycerol with arachidonoyl (20:4) side-chains attached at the C-1, C-2, and C-3 positions that is useful in lipid research.

  • GSK126

    Cayman Chemical

    A selective, SAM-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57 nM; IC50 = 9.9 nM versus that of EZH1: Ki = 89 nM; IC50 = 680 nM); inhibits global H3K27me3 levels, inhibiting the proliferation of EZH2 mutant DLBCL cell lines (IC50

  • 3-Methyladenine

    Cayman Chemical

    A specific inhibitor of PI3K activity and a widely used inhibitor of the autophagy; at 5 mM, inhibits protein degradation in rat hepatocytes by 65% and blocks class I, II, and III PI3Ks, including some downstream targets.

  • SB-431542

    Cayman Chemical

    A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM), ALK4 (IC50 = 140 nM) and, less effectively, ALK7; suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

  • Dithranol

    MP Biomedicals

    Dithranol (1, 8 - dihydroxy-9-anthrone) is also called as anthralin. It is a vital topical antipsoriatic drugs. Dithranol, an athracene derivative, is a free radical generating mitochondrial poison that induces apoptosis in keratinocytes. Dithranol may be used as a matrix for matrix assisted…

  • Hydrocortisone

    MP Biomedicals

    Hydrocortisone, a primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency. Hydrocortisone, known more formally as cortisone (INN, USAN, BAN), is a steroid hormone, produced by the zona…

  • (+)-Catechin

    LKT Labs

    Catechin is a flavanol originally found in Camilla and other plant sources; it exhibits antioxidative, anti-aging, anti-atherosclerotic, anti-ulcerative, neuroprotective, neuromodulatory, anticancer chemotherapeutic, and chemopreventive activities. Catechin increases life span in Caenorhabditis…

  • (+)-Abscisic Acid

    Cayman Chemical

    A plant hormone with diverse roles in disease resistance, plant development, and response to stresses; regulates gene expression and may contribute to epigenetic changes at the chromatin level.

  • T-2 Toxin

    Cayman Chemical

    A trichothecene mycotoxin that can infect grain crops causing alimentary toxic aleukia in humans and animals; inhibits protein synthesis, disrupts membrane phospholipid metabolism, increases lipid peroxides in the liver, and is highly cytotoxic to macrophages (IC50 = 19.47 nM), altering the…

  • Brassinazole

    Cayman Chemical

    An inhibitor of brassinosteroid biosynthesis that at 1 µM can induce morphological changes, including dwarfism and altered leaf color and curling, in dark-grown Arabidopsis and light-grown cress.

  • a-Tocotrienol

    Cayman Chemical

    The four tocopherols (α, β, .delta., and γ) and four tocotrienols (α, β, .delta., and γ) are forms of vitamin E, which is known for its antioxidant activity. Tocotrienols are found at high concentrations in palm oil and rice bran. Recent studies show tocotrienols…

  • Sunitinib Malate

    Cayman Chemical

    A small molecule, multi-targeted receptor tyrosine kinase inhibitor; potently inhibits signaling through PDGFR, VEGFR, KIT, and FLT3; inhibits both tumor cell growth and angiogenesis; approved by the FDA for the treatment of gastrointestinal stromal tumor and metastatic renal cell carcinoma.

  • 15-deoxy-?12,14-Prostaglandin J2-2-glycerol ester

    Cayman Chemical

    A glycerol ester analog of 15-deoxy-Δ12,14-PGJ2; there are no publications on its biological activity.

  • TBB

    Cayman Chemical

    An ATP/GTP-competitive inhibitor of CK2 (IC50 = 900 µM for rat liver CK2); less potently inhibits CCK2/cyclin A, GSK3β, and phosphorylase kinase (IC50 = 15.6, 11.2, and 8.7 mM, respectively); much less effective against a range of other kinases.

  • NBQX (sodium salt)

    Cayman Chemical

    A water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively); does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM).

  • 17-phenyl trinor Prostaglandin F2a methyl ester

    Cayman Chemical

    A lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor.

  • Aflatoxin B1

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin B1 is the most cytotoxic of all aflatoxins; it inhibits DNA synthesis and induces cell cycle arrest.

  • Moniliformin (sodium salt)

    Cayman Chemical

    A mycotoxin produced by fungi of the Fusarium genus that is phytotoxic to various agriculture grain crops, cardiotoxic to poultry and rats, and cytotoxic to human red blood cell progenitors (IC50 = 4.1 μM).

  • SureLight® PE-695

    Cayman Chemical

    Applications for SureLight® PE-695 Many applications and instruments were developed specifically for PE-695. It is commonly used in immunoassays such as FACS, flow cytometry, multimer/tetramer applications. With new instrumetation available, PE-695 is also well suited for…

  • Metformin (hydrochloride)

    Cayman Chemical

    A biguanide derivative used to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus; 50-400 mg/kg body weight inhibits complex 1 of the mitochondrial respiratory-chain and induces AMP-activated protein kinase-dependent signaling in B6-Lepob/ob mice.

  • Hypophyllanthin

    Cayman Chemical

    An active principle of P. amarus that has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.

  • APD668

    Cayman Chemical

    A potent agonist of GPR119 (EC50s = 2.7 and 33 nM for human and rat forms, respectively); significantly reduces blood glucose and glycated hemoglobin levels in Zucker diabetic fatty rats.

  • 5-fluoro Orotic Acid (hydrate)

    Cayman Chemical

    Used to detect URA3 gene expression in yeast molecular genetic constructs.

  • Perindoprilat

    Cayman Chemical

    The active metabolite of perindopril, an ACE inhibitor that has efficacy against hypertension; specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM.

  • Cefapirin

    Cayman Chemical

    A first generation cephalosporin antibiotic that is broadly effective against gram-negative and gram-positive bacteria; mainly used in veterinary medicine for intramammary treatment of mastitis and intrauterine treatment of endometritis in cattle.

  • Fluoxetine (hydrochloride)

    Cayman Chemical

    An SSRI, displaying a marked preference for the serotonin tranporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM).

  • Aminopterin

    LKT Labs

    Aminopterin is a folic acid analog and derivative of pterin; it is very similar to methotrexate in structure. Aminopterin exhibits anticancer chemotherapeutic and immunosuppressive activities. Like other folic acid analogs, aminopterin inhibits dihydrofolate reductase, depleting nucleotide pools…

  • TCEP (hydrochloride)

    Cayman Chemical

    An odorless, selective, and water-soluble reducing agent that is commonly used in many laboratory applications; commonly used to rapidly reduce protein and peptide disulfide bonds.

  • Fusarenon X

    Cayman Chemical

    A type B trichothecene mycotoxin found in cereals contaminated with certain Fusarium species.

  • Spiro-MeOTAD

    Cayman Chemical

    A stable and efficient hole-transport material in organic light-emitting devices and in ssDSSCs; yields high ssDSSC efficiency due to its excellent pore-filling property into mesoporous titania films.

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