Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Docetaxel

    Cayman Chemical

    A semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM); has applications in breast cancer and hormone-refractory prostate cancer; intended for research applications.

  • Cycloheximide

    Cayman Chemical

    An inhibitor of protein synthesis in eukaryotes (IC50 = 5-50 μM) that functions by interfering with translational elongation; can either induce or inhibit apoptosis depending on cell type.

  • FK-506

    Cayman Chemical

    A potent, clinically-useful immunosuppressant; binds to FK-506 binding protein 12 (Ki = 0.2 nM) to inhibit calcineurin; regulates NO neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and IP3 receptors.

  • Canthaxanthin

    LKT Labs

    Canthaxanthin is a carotenoid terpene pigment initially found in various sources including plants and fish. Canthaxanthin exhibits immunostimulatory, antioxidative, and chemopreventive activities; it does not display any vitamin A activity. In vivo, canthaxanthin increases cell-mediated and humoral…

  • (-)-YK-4-279

    Cayman Chemical

    A highly purified enantiomer of YK-4-279; properties have not been characterized.

  • Caffeic Acid

    LKT Labs

    Caffeic acid is a hydroxycinnamic acid found in coffee, argan oil, Eucaplyptus, Salvinia, and Phellinus; it exhibits antioxidative, anti-diabetic, antibiotic, anti-inflammatory, anti-metastatic, and anticancer activities. Caffeic acid inhibits activity of a-amylase and a-glucosidase. This compound…

  • Daidzin

    Cayman Chemical

    A naturally-occurring isoflavone with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.

  • G-418 Sulfate

    Cayman Chemical

    An aminoglycosidic antibiotic that is commonly used for the selection of genetically engineered cells neo neon toxic prokaryotic genes eukaryotic cells.

  • 17ß-Estradiol

    Cayman Chemical

    The major estrogen secreted by the premenopausal ovary.

  • 15-deoxy-?12,14-Prostaglandin A2

    Cayman Chemical

    A synthetic analog of PGA2 with structural features similar to 15-deoxy-Δ12,14-PGJ2, a ligand for PPARγ.

  • Puromycin (hydrochloride)

    Cayman Chemical

    An aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains; used in assays for peptide-bond formation and elongation and also often used as selective agent in cell culture systems.

  • Tamoxifen

    Cayman Chemical

    A selective estrogen receptor (ER) modulator; an ER antagonist in breast tissue, effective in treating early breast cancer; an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues.

  • 11-deoxy-11-methylene-15-keto Prostaglandin D2

    Cayman Chemical

    PGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor. However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2. This new…

  • Concanamycin A

    Cayman Chemical

    Blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.3 μM); blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.

  • Aeruginosin 722

    LKT Labs

    Aeruginosins are tetrapeptides found in cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosins inhibit serine proteases and protein phosphatases (PPs). In endothelial cells, aeruginosins decrease levels of IL-8 and ICAM-1 and inhibit NF-κB activity. Aeruginosins…

  • 4-hydroxy Nonenal Alkyne

    Cayman Chemical

    A form of 4-HNE with a terminal alkyne; for use in linking reactions (click chemistry) for detection of 4-HNE-modified DNA and proteins.

  • Amylin, human

    LKT Labs

    Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin from pancreatic ß-cells. Amylin is an endogenous peptide hormone that exhibits gastrointestinal motility modulating activity, decreasing gastric emptying and suppressing gastric acid secretion; these…

  • Myristic Acid Alkyne

    Cayman Chemical

    A form of the 14-carbon myristic acid with an ω-terminal alkyne group; can be used in linking reactions utilizing click chemistry.

  • Quercetin

    Cayman Chemical

    A flavonoid compound found in the bark and rinds of many plants and fruits.

  • Vinblastine (sulfate)

    Cayman Chemical

    An antimicrotubule drug used to treat Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer; inhibits steady-state tubulin addition to microtubules (Ki = 0.18 μM) and inhibits B16 melanoma cell proliferation (IC50 = 1 nM).

  • Makisterone A

    Cayman Chemical

    An ecdysteroid that drives molting in insects; binds the heterodimeric ecdysone receptor with nanomolar affinity.

  • Retinoic Acid

    Cayman Chemical

    A metabolite of vitamin A that acts as a ligand for both the RAR and the RXR.

  • Ceftazidime Hydrate

    LKT Labs

    Ceftazidime is a third generation β-lactam cephalosporin antibiotic. Ceftazidime exhibits antibacterial efficacy against most gram positive and some gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Grade: ≥97%

  • Bongkrekic Acid

    LKT Labs

    Bongkrekic acid is an antioxidative compound that inhibits mitochondrial respiration by preventing the mitochondrial permeability transition (MPT); it suppresses transport of ADP/ATP across the mitochondrial inner membrane, decreasing oxidative stress. Grade: ≥98%

  • CB-TH

    LKT Labs

    This peptide is a derivative of the N-terminal end of cecropin B and the C-terminal end of thanatin that exhibits antimicrobial peptide (AMP) activity. Grade: ≥95%

  • CEF10

    LKT Labs

    CEF peptides are v-Src-induced cytokines from chicken embryo fibroblasts. These peptides are biomarkers of CEF transformation by Rous sarcoma virus. Grade: ≥95%

  • Cerulenin

    LKT Labs

    Cerulenin is an inhibitor of fatty acid synthase found in Cephalosporium. Cerulenin exhibits antibiotic, antifungal, and anticancer chemotherapeutic activities. In cellular and animal models of colon cancer, cerulenin induces apoptosis and cellular death and decreases tumor growth. Cerulenin may…

  • Ceftiofur Hydrochloride

    LKT Labs

    Ceftiofur is a third generation β-lactam antibacterial used in livestock. Like other similar antibiotics, ceftiofur inhibits synthesis of bacterial cell walls by inhibiting penicillin binding proteins. Ceftiofur also displays anti-inflammatory activity. In vivo, this compound decreases…

  • Cerebellin

    LKT Labs

    Cerebellin is a neurexin-family cell adhesion peptide involved in synapse formation. Grade: ≥95%

  • Carcinoembryonic Antigen (605-613)

    LKT Labs

    This peptide is an epitope of carcinoembryonic antigen and is recognized by T cells in the immune system; it may have potential in the development of vaccines or targeting therapies. Grade: ≥95%

  • Cefuroxime Sodium

    LKT Labs

    Cefuroxime is a second generation semi-synthetic cephalosporin antibiotic that inhibits penicillin binding proteins. Cefuroxime is a β-lactam antibiotic that exhibits antibacterial activity against gram positive and gram negative bacteria, including species of Haemophilus, Enterobacteriaceae,…

  • Cefaclor Monohydrate

    LKT Labs

    Cefaclor is a second generation β-lactam cephalosporin antibiotic. Cefaclor exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefaclor also displays…

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