Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Aceclofenac

    LKT Labs

    Aceclofenac is a diclofenac analog that exhibits anti-inflammatory and analgesic activities. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that somewhat selectively inhibits COX-2; it is clinically used to treat rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.…

  • Adrenomedullin (1-52), human

    LKT Labs

    Adrenomedullin is an endogenous peptide hormone involved in growth and differentiation of stem cells. This peptide exhibits vasodilatory, natriuretic, and cardioprotective activities. Adrenomedullin decreases blood pressure and increases neovascularization. This peptide binds microtubule-associated…

  • Microcystin-RR

    Cayman Chemical

    A toxin produced by cyanobacteria that inhibits the catalytic activity of protein phosphatases PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.

  • Quercetin

    Cayman Chemical

    A flavonoid compound found in the bark and rinds of many plants and fruits.

  • Ac-IETD-pNA

    LKT Labs

    Ac-IETD-pNA is a peptide substrate used to measure activity of caspase 8. Grade: ≥95%

  • Actinomycin

    LKT Labs

    Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…

  • (R)-Butaprost (free acid)

    Cayman Chemical

    Butaprost is a structural analog of PGE2 with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.{3317} Serious confusion as to the structure of butaprost was…

  • Acivicin

    LKT Labs

    Acivicin is a fermentation product of Streptomyces; it is a glutamine analog. Acivicin inhibits ?-glutamyl transferase, CTP synthetase, GMP synthetase, and FGAM synthetase, preventing purine synthesis. Acivicin exhibits anticancer and antifungal activity, although its potential chemotherapeutic…

  • Adrenocorticotropic Hormone (1-4)

    LKT Labs

    Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…

  • 10(S),17(S)-DiHDHA

    Cayman Chemical

    A DHA metabolite, also referred to as protectin DX (PDX), produced by an apparent double lipoxygenase-mediated reaction; blocks neutrophil infiltration in mouse peritonitis by 20-25% at a dose of 1 ng/mouse; inhibits platelet activation by both impairing TX synthesis and TX receptor activation.

  • 3-amino Benzamide

    Cayman Chemical

    An inhibitor of poly(ADP-ribose) polymerases (PARPs) (Ki = 1.8 μM); has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

  • N-Acetyl-S-(N'-phenethylthiocarbamoyl)-L-cysteine

    LKT Labs

    This compound is an N-acetyl cysteine conjugate of phenethylisothiocyanate (PEITC-NAC), exhibiting anticancer chemotherapeutic and chemopreventive activities. In lung cancer and prostate cancer models, PEITC-NAC increases activation of JNK, p53, and MAPKs, inducing apoptosis, decreasing tumor…

  • N-Acetyl-D-Leucine

    LKT Labs

    N-acetyl-D-leucine is a D-amino acid that is deacylated in bacteria by d-aminoacylase enzymes. D-amino acids inhibit bacterial biofilm formation when they are incorporated into the cell wall. Compounds such as N-acetyl-D-leucine induce release of amyloid fibers that link cells together in the…

  • Acetyl-L-Carnitine

    LKT Labs

    Acetyl-L-carnitine is a derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65,…

  • Acitretin

    LKT Labs

    Acitretin is an orally bioavailable retinoid that displays anti-inflammatory activity and is used clinically to treat psoriasis. Acitretin is a metabolite of etretinate that displays more optimized pharmacokinetic parameters. This compound activates all retinoic acid receptor subtypes…

  • Acetyl-L-Carnitine Hydrochloride

    LKT Labs

    Acetyl-L-carnitine is a derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65,…

  • Acetylsalicylic Acid

    LKT Labs

    NSAID and COX-1/2 inhibitor used to decrease inflammation. It inhibits platelet aggregation and prolongs bleeding time by decreasing levels of thromboxane A2. Chronic administration decreases risk of cancer and cardiovascular events.

  • N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine

    LKT Labs

    This compound is a conjugate of N-acetyl-cysteine and sulforaphane. Like other isothiocyanates (ITCs), this compound likely displays antioxidative activity. Grade: ≥98%

  • Acarbose

    LKT Labs

    a-Glucosidase inhibitor that decreases digestion of complex carbohydrates and prevents glucose absorption. It improves insulin sensitivity and decreases postprandial hyperglycemia.

  • SRT 1720 (hydrochloride)

    Cayman Chemical

    A selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol; improves insulin sensitivity, lowers plasma, glucose and increases mitochondrial capacity in diet-induced obese and diabetic leptin-deficient ob/ob mice after one week of treatment with an oral dose of…

  • Ethyl-L-NIO (hydrochloride)

    Cayman Chemical

    A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).

  • Ac-IEAR-pNA

    LKT Labs

    Ac-IEAR-pNA is a peptide substrate used to measure activity of caspases. Grade: ≥95%

  • Ac-GPK(Ac)-pNA, 25 mg

    LKT Labs

    Ac-IEAR-pNA is a peptide substrate used to measure activity of caspases. Grade: ≥95%

  • Abamectin

    LKT Labs

    F0F1-ATPase and adenine nucleotide translocator inhibitor and GABA receptor antagonist. It prevents mitochondrial respiration and decreases sperm count and motility. Grade: ≥70%

  • Abacavir Sulfate

    LKT Labs

    Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection. Grade: ≥98%

  • Glycerol Tri-y-Linolenoyl

    Cayman Chemical

    Molecular Formula: C57H92O6 Formula Weight: 873.4

  • Acipimox

    LKT Labs

    Acipimox is a niacin derivative that acts as an anti-hyperlipidemic. Acipimox decreases levels of triglycerides, LDL, and free fatty acids, and increases levels of HDL. Acipimox decreases cAMP levels and AMPK activity, suppressing lipolysis by lipase. Grade: ≥98%

  • PDM 11

    Cayman Chemical

    A structural analog of several resveratrol derivatives which act as a potent and selective AhR antagonists and agonist.

  • (±)12(13)-DiHOME

    Cayman Chemical

    A metabolite of (±)12(13)-EpOME.

  • Ac-GPK-pNA

    LKT Labs

    Substrate used to measure caspase activity.

  • Ac-D-E

    LKT Labs

    Mast cell stabilizer used to treat seasonal allergic rhinitis.

  • A66

    LKT Labs

    Inhibitor of p110a PI3K. It decreases viability of endometrial cancer cells and impairs glucose and insulin tolerance.

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