Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)

    Cayman Chemical

    A synthetic analog of natural PtdIns containing C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

  • Palmitic Acid

    Cayman Chemical

    A common 16-carbon saturated fatty acid that represents 10-20% of the normal human dietary fat intake.

  • L-Biopterin

    Cayman Chemical

    L-Biopterin is the oxidized form of BH4, a NOS cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs). L-Biopterin is rarely found…

  • 7-piperazin-1-yl-Isoquinoline (hydrochloride)

    Cayman Chemical

    7-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

  • Pyrimidin-4-yl-Methanol

    Cayman Chemical

    Pyrimidin-4-yl-Methanol is a synthetic intermediate useful for pharmaceutical synthesis.

  • PD 0325901

    Cayman Chemical

    A potent MEK inhibitor that suppresses phosphorylation of ERK in murine colon 26 tumors with an IC50 value of 0.33 nM; suppression of ERK activation with 1 µM PD 0325901 combined with 3 µM CHIR99021 (a glycogen synthase kinase-3 inhibitor) prevents cell differentiation and sustains self…

  • Oleyl Anilide

    Cayman Chemical

    AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. OA is a weak inhibitor of ACAT with an IC50 of 26 µM. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a…

  • 2-NBDG

    Cayman Chemical

    A fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues; also used as a topical contrast reagent for the detection of neoplasia.

  • PDM 2

    Cayman Chemical

    A potent and selective AhR antagonist (Ki = 1.2 nM).

  • Abamectin

    LKT Labs

    F0F1-ATPase and adenine nucleotide translocator inhibitor and GABA receptor antagonist. It prevents mitochondrial respiration and decreases sperm count and motility.

  • 2,3-dinor Thromboxane B1

    Cayman Chemical

    TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.{12600,12599} However in human urine, only trace…

  • Elaidic Acid

    Cayman Chemical

    Elaidic acid is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils. In human platelets incubated with arachidonic acid, elaidic acid inhibits HHT and HETE formation while inducing prostaglandin and thromboxane synthesis.{2046}

  • Acetylsalicylic Acid

    LKT Labs

    NSAID and COX-1/2 inhibitor used to decrease inflammation. It inhibits platelet aggregation and prolongs bleeding time by decreasing levels of thromboxane A2. Chronic administration decreases risk of cancer and cardiovascular events.

  • Leukotriene B4

    Cayman Chemical

    A key dihydroxy fatty acid derived from AA through the 5-LO pathway; promotes a number of leukocyte functions including chemotaxis and chemokinesis at subnanomolar concentrations.

  • 4-bromo-A23187

    LKT Labs

    Non-fluorescent halogenated A23187 analog and Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acros

  • Acarbose

    LKT Labs

    a-Glucosidase inhibitor that decreases digestion of complex carbohydrates and prevents glucose absorption. It improves insulin sensitivity and decreases postprandial hyperglycemia.

  • Abacavir Sulfate

    LKT Labs

    Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection.

  • D,L-1'-Acetoxychavicol Acetate

    LKT Labs

    TRPA1 channel agonist and xanthine oxidase inhibitor. It increases levels of phase II enzymes in models of colon carcinogenesis and suppresses tumor growth in animal models of squamous cell carcinoma. In other cancer models, it prevents angiogenesis an

  • Abiraterone

    LKT Labs

    Progesterone derivative and Cyp17A1 inhibitor used to treat castration-resistant prostate cancer. It decreases androgen production and may inhibit eIF4F signaling.

  • Abacavir

    LKT Labs

    Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection.

  • A66

    LKT Labs

    Inhibitor of p110a PI3K. It decreases viability of endometrial cancer cells and impairs glucose and insulin tolerance.

  • Acemetacin

    LKT Labs

    Prodrug of indomethacin, NSAID, and COX-1/2 inhibitor used to treat pain and arthritis. It also scavenges ROS and RNS.

  • BAM-22P

    LKT Labs

    κOR and µOR agonist and cleavage product of proenkephalin.

  • 15-Acetoxyscirpenol

    LKT Labs

    Mycotoxin found in Fusarium. It induces apoptosis in Jurkat T cells.

  • ABT-199

    LKT Labs

    BH3 mimetic and Bcl-2 inhibitor. It induces apoptosis in chronic lymphocytic leukemia cells

  • BAM-12P

    LKT Labs

    Bovine adrenal medulla 12 peptide (BAM-12P) is a cleavage product of proenkephalin that binds κ-opioid receptors (κORs). BAM-12P plays a role in antinociceptive signaling.

  • A23187 Ca-Mg

    LKT Labs

    Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acrosome reaction in spermatozoa.

  • 17-Allylaminogeldanamycin

    LKT Labs

    Geldanamycin derivative and HSP90 inhibitor. It induces apoptosis in cancer cells and inhibits replication of cytomegalovirus.

  • A-779

    LKT Labs

    Mas antagonist that inhibits signaling by angiotensin (1-7), preventing vasodilation and insulin sensitization.

  • ABT-263

    LKT Labs

    BH3 mimetic and inhibitor of Bcl-2, Bcl-?, and Bcl-xl. It enhances the efficacy of co-administered chemotherapeutics and inhibits proliferation of chronic lymphocytic leukemia cells.

  • D-myo-Inositol-1,4,6-triphosphate (sodium salt)

    Cayman Chemical

    Ins(1,4,6)-P3 is a member of the InsP family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.…

  • Arachidonoyl-N,N-dimethyl amide

    Cayman Chemical

    An analog of AEA that exhibits weak or no binding to the human CB1 receptor (Ki >1 µM); inhibits rat glial gap junction cell-cell communication at a concentration of 50 µM.

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