Features
- Reversed phase nano silica impregnated with Cu(II) ions and a chiral selector (a proline derivative, DP 31 43 726 and EP 0 143 147)
- Separation based on ligand exchange, i. e. formation of ternary mixed-ligand complexes with the Cu(II) ions
- differences in the stability of the diastereomeric complexes cause chromatographic separation
- Available as glass plates with fluorescent indicator
Recommended application: enantiomer separation of amino acids, N-methylamino acids, N-formylamino acids, α-alkylamino acids, thiazolidine derivatives, dipeptides, lactones, α-hydroxycarboxylic acids