The Silicon-A-HRC Plate can be used in centrifuges for large-scale (i.e., 96-well) purification of DNA and/or RNA. Its low-profile, durable polypropylene construction and unique matrix make it ideal for removing polyphenolic compounds (e.g. melanin, humic acids, tannins, etc.) that can inhibit PCR and RT in non-pure DNA and RNA preparations, respectively. Capacity is 100 micro liter per well.