In areas like drug discovery where target compounds are increasingly polar, it is critical to have a reversed-phase column that performs well under aqueous conditions. Retention is critical, but cannot come with troublesome secondary interactions. From the collapse-resistant pore structure of…

General Description SUPELCOSIL LC-18-S columns are designed for reliable separations of deoxyribonucleosides and ribonucleosides. Legal Information SUPELCOSIL is a trademark of Sigma-Aldrich Co. LLC

The Ascentis family of columns is the fourth generation of HPLC column technology from Supelco scientists. Ascentis columns are bonded on high purity, 100 Angstrom silica including 3, 5, and 10 micron particle size. Columns are designed for small molecule applications and are scalable from micro…

SUPELCOSIL LC-DB phases are specially deactivated for basic compounds. These columns provide shorter retention, better peak shape, and higher efficiency for organic bases than can be obtained on other Type A silica reversed-phase columns. Legal Information SUPELCOSIL is a trademark of…

In a reversed-phase mode, Cyano columns are the most polar and least retentive of all reversed-phase packings. Extremely hydrophobic compounds, which do not elute on standard C18 and C8 packings with typical reversed-phase eluents, can be chromatographed using Cyano columns. In addition, the unique…

Verify optimum selectivity of Thermo Scientific* Accucore HPLC columns for polar analytes. Based on Core Enhanced Technology, Accucore columns provide fast, high-resolution separations - without the elevated backpressures required by sub-2µm particles. Fast separations with excellent…

A special C18 phase that is recommended for the separation of polar compounds thatrequire high aqueous mobile phase conditions. Hydrophilic endcapping keeps theC18 chains fully extended into the mobilephase, even when using aqueous mobile phases with no organic modifier. The result is better…

eCl@ss: 32110501 Features and Benefits Excellent reproducibility Faster separation of strongly hydrophobic analytes than C18 columns Stable, low-bleed LC-MS separations Exceptional peak shapes for basic and acidic compounds Compatible with low organic/highly aqueous…

Application: TSKgel® UP-SW3000 HPLC Column may be used for the separation of: •Free payloads and related species from antibody drug conjugates (ADCs) and their aggregates, during their determination by using 1-dimensional (1D) gradient size exclusion chromatography (SEC). •Protein…

NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties: Totally spherical particle shape Outstanding surface microstructure High pressure stability Low metal content NUCLEODUR® as a state-of-the-art silica…

SMT manufactures ultra-stable cyanopropyl [CN] packings for normal and reversed-phase chromatographic separation modes. These columns have some special characteristics. When used in normal phase mode, with relatively nonpolar solvents, CN-stationary phase can separate many polar compounds just like…

YMC-Pack C4 (Butyl) columns are less hydrophobic than C8 or C18 packings, and generally utilize more aqueous eluents than either of these reversed phase column types. When compared to C8 and C18 columns using the same eluent, C4 columns show significantly shorter retention for non-polar compounds.…

C8 is the most commonly used column type following C18. YMC Octyl columns are prepared from exhaustive bonding of a monomeric octylsilane to totally spherical and porous silica gels. The functionalized silica is then treated with a endcapping process. Application: For Anti-Human Immunodeficiency…

YMC-Pack Diol is a size exclusion chromatography column utilizing a silica gel base. Diol-120, 200, and 300 are suitable for separation or molecular weight determination of proteins with molecular weights of 10,000 to 1,000,000. Diol-60 is the most suitable for separation of peptides of…

Features and Benefits Enhanced stability at low pH Operates in reversed-phase, HILIC, and normal phase modes of chromatography Low MS bleed 100% aqueous compatible Available as 3 μm and 5 μm particles Particle composition: Type B silica gel Particle shape: Spherical…

Application: UHPLC Analysis of Sunscreens on Ascentis® Express RP-Amide, 2.7 mumU/HPLC Analysis of Phenolic Acids on Ascentis® Express RP-Amide, 2.7 mum Legal Information: Fused-Core is a registered trademark of Advanced Materials Technology, Inc.

Use Discovery® C18 for any method that specifies a C18. The exceptional peak shape, reproducibility, and stability make it the column of choice for all C18 methods from demanding to routine. Legal Information: Discovery is a registered trademark of Sigma-Aldrich Co. LLC

YMCbasic is a unique reversed-phase column designed for analysis of pharmaceuticals and other basic compounds. YMCbasic utilizes a novel silica synthesis and state-of-art silane bonding to create a column which gives true reversed-phase character, high resolution and excellent peak shape for the…

As a workhorse for HPLC method development, XBridge BEH C18 sorbent can be used over an entire range of mobile phase pH (1-12). The trifunctionally bonded C18 ligand provides you with a universal column for most HPLC separations and gives you the widest usable pH range, superior low pH stability,…

NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties: Totally spherical particle shape Outstanding surface microstructure High pressure stability Low metal content NUCLEODUR® as a state-of-the-art silica…

Proteomix ion-exchange phases have been innovatively developed for achieving high ion-exchange capacity, a breakthrough technology for non-porous resins. Proteomix packing support is composed of a rigid, spherical, highly cross-linked poly(styrene divinylbenzene) (PS/DVB) non-porous bead with…

Discovery® HS C18 HPLC column (L x I.D. 5 cm x 2.1 mm) is commonly found to be stable under acidic and basic conditions. Legal Information: Discovery is a registered trademark of Sigma-Aldrich Co. LLC

Purospher® STAR RP-18 endcapped is the best choice for HPLC separation of basic, neutral, metal chelating samples or indeed any other format. Its outstanding performance and stability, allows a maximum flexibility in method development. Robust methods can be developed across the entire pH…

Polyaromatic hydrocarbons (PAH?s) are large organic compounds produced during combustion. Many of these compounds are carcinogenic and are often found in water, air and other natural habitats. Monitoring of these compounds is very crucial for a healthy environment. The major challenge in HPLC…

SMT manufactures the most reliable silica based octadecyl (C18) column available in the market today. This advanced new column is very stable at a wide pH range and high temperatures. SMT utilizes a proprietary bonding scheme that allows the resulting bonded phases to perform separation of basic,…

Proteomix ion-exchange phases have been innovatively developed for achieving high ion-exchange capacity, a breakthrough technology for non-porous resins. Proteomix packing support is composed of a rigid, spherical, highly cross-linked poly(styrene divinylbenzene) (PS/DVB) non-porous bead with…

SMT manufactures the most reliable silica based packing materials available in the market today. When silica is used as the stationary phase, the functional groups involved in separation are the surface silanols. However, metal impurities in silica may provide additional sites of interaction for…

Synonym: Partisil™ HPLC Column eCl@ss 32110501

SMT manufactures columns with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation substrate…

Legal Information: Supelguard is a trademark of Sigma-Aldrich Co. LLC

ODS-A in 120Å pore size is the first choice of many chromatographers for high performance reversed phase separations. It has selectivity for the separation of a wide range of organic compounds found in pharmaceutical, chemical and biotechnology industries. ODS-A is a high coverage, fully endcapped…

NUCLEOSIL® is a family of totally porous spherical silicas with a very pure and uniform SiO2 structure Wide acceptance as routine packings for very different fields of chromatography One of the first spherical silicas used in HPLC Developed in the early seventies, it became a…