AlumVax Hydroxide is a crystalline aluminum oxyhydroxide that is positively charged at physiological pH (pI=11), suitable for adsorption of negatively charged, acidic proteins (such as albumin) provided as a wet gel (colloidal) of aluminum hydroxide 2% for a ready-to-use suspension.
Aluminum hydroxide is the most common adjuvant used in approved prophylactic vaccines because of its excellent safety profile and ability to enhance protective humoral immune response. Since more than 80 years, it has been observed that aluminium compounds act by a depot effect and also by direct activation of the immune cells. Adsorption or entrapment of antigens in aggregates through hydrophobic and electrostatic interactions favors a high local antigen concentration and improved uptake by antigen presentating cells (APC). |