Synonyms: Turbo Grignard
Formula: C3H7Cl2LiMg
Formula Weight: 145.24
Linear Formula: (CH3)2CHMgCl · LiCl
MDL No.: MFCD07784514
Density: 0.951 g/mL at 25 C
UNSPSC Code: 12352103
Application: Reagent for Selective MetalationsUsed for:. Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones. Preparation of cyclic alkenyl and dienyl magnesium reagents. Preparation of functionalized triazenes/preparation of carbazoles. Regioselective functionalization of trisubstituted pyridines. Electrophilic amination for preparation of amines. Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins). Preparation of Benzylic Grignards via Sulfur-Magnesium exchange. Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids. Functionalization via I-Mg Exchange of unprotected imidazoles. Pyridyne formation. Functionalization of cyclopentene derivatives. Preparation of 2,3-functionalized furans, benzofurans, and thiophenes. Stereoselective synthesis of substituted cyclopropanes
Application: Reagent used with CH3MgCl/LiCl to affect magnesium-halogen exchange on unprotected aryl carboxylic acids.
RIDADR: UN 3399BC 4.3(3) / PGII
WGK Germany: 3
Flash Point(F): 1.4 F
Flash Point(C): -17 C
R Codes: 11-14/15-19-34-37-40
S Codes: 16-26-36/37/39-43-45
IOD Codes: F,C
Symbol: GHS02, GHS05, GHS07, GHS08
Signal Word: Danger
Hazard Statements: H225-H314-H335-H351
Precautionary statements: P210-P260-P280-P305 + P351 + P338-P370 + P378-P403 + P235