Rotenone is a naturally occurring botanical compound obtained from the roots of Derris sp.& Cube. It is an inhibitor of mitochondrial electron transport, specifically inhibiting NAD-linked substrate oxidation by mitochondria at the oxygen side of NADH dehydrogenase.
Rotenone is utilized as an insecticide. It can be used as neurotoxic agent that can produce a Parkinson-like condition as an animal model for study of etiology and interventions.
Inhibitor of mitochondrial electron transport at NADH: ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone is used to induce a Parkinson-like syndrome as an experimental model in rats.
Purity: ≥97%
Key Applications: Insectiside, Piscicide, Neurotoxic agent
Application Areas: Cell Signaling
Product Type: Biochemicals
Chemical Class: Pharmaceuticals
Density: 1.27 at 20°C (Lit.)
Boiling Point: 210-220°C/0.5 mmHg(lit.)
Melting Point: 159-164°C(lit.)
Vapor Pressure: <1 x 10-5 mbar at 20°C
Extinction Coefficient (E1%): 19.2 (294 nm, ethanol)(Lit.)
Partition Coefficient: Octanol/Water Partition Coefficient-log Kow = 4.10 (Lit.)
Optical Rotation: -120° (1.38 g/100 mL chloroform at 25°C) (Lit.)
Presentation: Off-white Powder
Solubility: Insoluble in water; Soluble in ethanol, methanol, acetone, carbon tetrachloride, chloroform, ether, or benzene.
Storage & Handling: Room Temperature, protect from light, store under nitrogen