SYT4 (synaptotagmin 4) gene is localized on human chromosome 18q12.3. Its mRNA is predominantly expressed in hippocampus of human brain, and shows lesser expression in amygdala and thalamus. This protein is a member of the SYT protein family. In PC12 (pheochromocytoma) cell line, it is expressed in endoplasmic reticulum-Golgi complexes and secretory granules. In culture neurons, this protein localizes to axonal processes. This protein forms a part of neuroendocrine system.
Synonyms: Anti-HsT1192; Anti-KIAA1342; Anti-synaptotagmin IV
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SYT4 (synaptotagmin 4) protein is thought to play a role in human brain functioning and neurological disorders. SYT4 null mice die shortly after birth. It is an atypical regulator of synaptic exocytosis, and also negatively controls the exocytosis of oxytocin. In dietary obesity, there is an increased vesicle binding of SYT4, which leads to increased negative regulation of oxytocin exocytosis.
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